{
 "built": "2026-09-12",
 "sources": {
  "clp": {
   "label": "EU harmonised classification (CLP Annex VI, ATP23, Delegated Regulation (EU) 2025/1222)",
   "url": "https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp",
   "authority": "Binding EU regulation: classification and labelling are mandatory for substances and mixtures; harmonised entries adopted by Commission delegated acts after ECHA RAC opinions."
  },
  "p65": {
   "label": "California Proposition 65 list, developmental toxicants",
   "url": "https://oehha.ca.gov/proposition-65/proposition-65-list",
   "authority": "Binding Californian law: warnings required before exposure; the list is revised at least once a year by OEHHA."
  },
  "ema": {
   "label": "EMA pregnancy prevention programmes and contraindications",
   "url": "https://www.ema.europa.eu/en/human-regulatory-overview/post-authorisation/pharmacovigilance-post-authorisation/referral-procedures-human-medicines",
   "authority": "Binding in the EU through marketing authorisations and referral decisions; the medicines stay authorised but with conditions."
  },
  "who": {
   "label": "WHO fact sheet on congenital disorders",
   "url": "https://www.who.int/news-room/fact-sheets/detail/birth-defects",
   "authority": "Guidance, not binding; WHO keeps no list of teratogens."
  },
  "bib": {
   "label": "DysNet bibliography (peer-reviewed literature)",
   "url": "/knowledge/research-library/",
   "authority": "Scientific evidence, no regulatory effect."
  }
 },
 "counts": {
  "total": 579,
  "clp": 306,
  "p65": 300,
  "ema": 12,
  "both_clp_and_p65": 32
 },
 "entries": [
  {
   "name": "1,1-Dichloro-2,2-bis(p-chloropheny)ethylene (DDE)",
   "cas": "72-55-9",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental, male",
     "mechanism": "authoritative body",
     "listed": "2010-03-30",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Dichlorodiphenyldichloroethylene",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "1,2-diethoxyethane",
   "cas": "629-14-1",
   "ec": "211-076-1",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1A",
     "statements": [
      "H360Df"
     ],
     "developmental_specific": true,
     "atp": "ATP01",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32009R0790",
     "index": "603-208-00-5"
    }
   ],
   "status": {
    "clp": "known"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Ethylene_glycol_diethyl_ether",
   "level": "known",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "1,3-Butadiene",
   "cas": "106-99-0",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental, female, male",
     "mechanism": "authoritative body",
     "listed": "2004-04-16",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Butadiene",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "1,4-Butanediol dimethanesulfonate (Busulfan)",
   "cas": "55-98-1",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "State's Qualified Experts",
     "listed": "1989-01-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Busulfan",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) (Lomustine)",
   "cas": "13010-47-4",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1990-07-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Lomustine",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "1-bromopropane; n-propyl bromide",
   "cas": "106-94-5",
   "ec": "203-445-0",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360FD"
     ],
     "developmental_specific": true,
     "atp": "CLP00",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "602-019-00-5"
    },
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental, female, male",
     "mechanism": "authoritative body",
     "listed": "2004-12-07",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "clp": "presumed",
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    },
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/1-Bromopropane",
   "level": "known",
   "source_codes": [
    "clp",
    "p65"
   ]
  },
  {
   "name": "2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)",
   "cas": "1746-01-6",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "authoritative body",
     "listed": "1991-04-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/2,3,7,8-Tetrachlorodibenzodioxin",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "2,4-D butyric acid [Click here for the basis for the removal of developmental endpoint, effective June 22, 2001]",
   "cas": "94-82-6",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental,   male",
     "mechanism": "authoritative body",
     "listed": "1999-06-18",
     "madl_ug_day": "910",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/2,4-DB",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "2,4-Diamino-6-chloro-s-triazine (DACT)",
   "cas": "3397-62-4",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental, female",
     "mechanism": "authoritative body",
     "listed": "2016-07-15",
     "madl_ug_day": "100 (oral)",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": null,
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "2,4-DP (dichloroprop)  Delisted January 25, 2002 [Click here for the basis for delisting]",
   "cas": "120-36-5",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "authoritative body",
     "listed": "1999-04-27",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Dichlorprop",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "2-ethoxyethanol; ethylene glycol monoethyl ether",
   "cas": "110-80-5",
   "ec": "203-804-1",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360FD"
     ],
     "developmental_specific": true,
     "atp": "ATP03",
     "applies_from": "2013-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32012R0618",
     "index": "603-012-00-X"
    },
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental, male",
     "mechanism": "State's Qualified Experts",
     "listed": "1989-01-01",
     "madl_ug_day": "750 (oral)\n960 (inhalation)",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "clp": "presumed",
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    },
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/2-Ethoxyethanol",
   "level": "known",
   "source_codes": [
    "clp",
    "p65"
   ]
  },
  {
   "name": "2-ethoxyethyl acetate; ethylglycol acetate",
   "cas": "111-15-9",
   "ec": "203-839-2",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360FD"
     ],
     "developmental_specific": true,
     "atp": "ATP01",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32009R0790",
     "index": "607-037-00-7"
    },
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental, male",
     "mechanism": "authoritative body",
     "listed": "1993-01-01",
     "madl_ug_day": "1100 (oral)\n1400 (inhalation)",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "clp": "presumed",
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    },
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/2-Ethoxyethyl_acetate",
   "level": "known",
   "source_codes": [
    "clp",
    "p65"
   ]
  },
  {
   "name": "2-Ethylhexanoic acid  Delisted December 13, 2013 [Click here for the basis for delisting]",
   "cas": "149-57-5",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "Labor Code",
     "listed": "2009-08-07",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/2-Ethylhexanoic_acid",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "2-methoxyethanol; ethylene glycol monomethyl ether",
   "cas": "109-86-4",
   "ec": "203-713-7",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360FD"
     ],
     "developmental_specific": true,
     "atp": "CLP00",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "603-011-00-4"
    },
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental, male",
     "mechanism": "State's Qualified Experts",
     "listed": "1989-01-01",
     "madl_ug_day": "63 (oral)",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "clp": "presumed",
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    },
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/2-Methoxyethanol",
   "level": "known",
   "source_codes": [
    "clp",
    "p65"
   ]
  },
  {
   "name": "2-methoxyethyl acetate; methylglycol acetate",
   "cas": "110-49-6",
   "ec": "203-772-9",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360FD"
     ],
     "developmental_specific": true,
     "atp": "CLP00",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "607-036-00-1"
    },
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental, male",
     "mechanism": "authoritative body",
     "listed": "1993-01-01",
     "madl_ug_day": "98 (oral)",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "clp": "presumed",
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    },
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": null,
   "level": "known",
   "source_codes": [
    "clp",
    "p65"
   ]
  },
  {
   "name": "3,5-dibromo-4-hydroxybenzonitrile; bromoxynil (ISO); bromoxynil phenol",
   "cas": "1689-84-5",
   "ec": "216-882-7",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361d"
     ],
     "developmental_specific": true,
     "atp": "CLP00",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "608-006-00-0"
    },
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1990-10-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "clp": "suspected",
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    },
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Bromoxynil",
   "level": "known",
   "source_codes": [
    "clp",
    "p65"
   ]
  },
  {
   "name": "4,4'-sulphonyldiphenol; bisphenol S",
   "cas": "80-09-1",
   "ec": "201-250-5",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360FD"
     ],
     "developmental_specific": true,
     "atp": "ATP18",
     "applies_from": "2023-11-23",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32022R0692",
     "index": "604-098-00-1"
    },
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "State's Qualified Experts",
     "listed": "2025-12-08",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "clp": "presumed",
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    },
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Bisphenol_S",
   "level": "known",
   "source_codes": [
    "clp",
    "p65"
   ]
  },
  {
   "name": "Abiraterone acetate",
   "cas": "154229-18-2",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental, female, male",
     "mechanism": "formally required to be labelled or identified",
     "listed": "2016-04-08",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Abiraterone_acetate",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Acetazolamide",
   "cas": "59-66-5",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1999-08-20",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Acetazolamide",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Acetohydroxamic acid",
   "cas": "546-88-3",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1990-04-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Acetohydroxamic_acid",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Acrylamide",
   "cas": "79-06-1",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental, male",
     "mechanism": "authoritative body",
     "listed": "2011-02-25",
     "madl_ug_day": "140",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Acrylamide",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Actinomycin D",
   "cas": "50-76-0",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1992-10-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Dactinomycin",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Alcohol (ethanol) in beverages",
   "cas": "64-17-5",
   "ec": "",
   "kind": "product",
   "sources": [
    {
     "label": "WHO fact sheet on congenital disorders",
     "code": "who",
     "note": "WHO names alcohol among harmful substances to avoid in pregnancy; foetal alcohol spectrum disorders are a recognised consequence of prenatal exposure.",
     "url": "https://www.who.int/news-room/fact-sheets/detail/birth-defects"
    }
   ],
   "status": {
    "who": "known"
   },
   "jurisdictions": {
    "EU / EEA": "Legal; no EU-wide pregnancy warning is mandatory on labels (Regulation 1169/2011 exempts alcoholic beverages from ingredient and nutrition labelling).",
    "France": "Legal; a pregnancy warning message or pictogram is mandatory on every alcoholic beverage (arrêté of 2 October 2006)."
   },
   "wiki": "https://en.wikipedia.org/wiki/Ethanol",
   "level": "known",
   "source_codes": [
    "who"
   ]
  },
  {
   "name": "All-trans retinoic acid",
   "cas": "302-79-4",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "State's Qualified Experts",
     "listed": "1989-01-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Tretinoin",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Alprazolam",
   "cas": "28981-97-7",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1990-07-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Alprazolam",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Altretamine",
   "cas": "645-05-6",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental, male",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1999-08-20",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Altretamine",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Amantadine hydrochloride",
   "cas": "665-66-7",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "2001-02-27",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Amantadine",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Amikacin sulfate",
   "cas": "39831-55-5",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1990-07-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Amikacin",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Aminoglutethimide",
   "cas": "125-84-8",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1990-07-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Aminoglutethimide",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Aminoglycosides",
   "cas": "",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1992-10-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Aminoglycoside",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Aminopterin",
   "cas": "54-62-6",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental, female",
     "mechanism": "State's Qualified Experts",
     "listed": "1987-07-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Aminopterin",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Amiodarone hydrochloride",
   "cas": "19774-82-4",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental, female, male",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1997-08-26",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Amiodarone",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Amitraz",
   "cas": "33089-61-1",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "authoritative body",
     "listed": "1999-03-30",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Amitraz",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Amoxapine",
   "cas": "14028-44-5",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1998-05-15",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Amoxapine",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Angiotensin converting enzyme  (ACE) inhibitors",
   "cas": "",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1992-10-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Angiotensin-converting_enzyme",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Anisindione",
   "cas": "117-37-3",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1992-10-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Anisindione",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Arsenic (inorganic oxides)",
   "cas": "",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "State's Qualified Experts",
     "listed": "1997-05-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Arsenic",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Aspirin (NOTE:  It is especially  important not to use aspirin during the last three months of pregnancy,  unless specifically directed to do so by a physician because it may cause  problems in the unborn child or  complications during delivery.)",
   "cas": "50-78-2",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental, female",
     "mechanism": "State's Qualified Experts",
     "listed": "1990-07-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Aspirin",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Atenolol",
   "cas": "29122-68-7",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1997-08-26",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Atenolol",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Atrazine",
   "cas": "1912-24-9",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental, female",
     "mechanism": "authoritative body",
     "listed": "2016-07-15",
     "madl_ug_day": "100 (oral)",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Atrazine",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Auranofin",
   "cas": "34031-32-8",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1999-01-29",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Auranofin",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Avermectin B1 (Abamectin)",
   "cas": "71751-41-2",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "authoritative body",
     "listed": "2010-12-03",
     "madl_ug_day": "4.4000000000000004",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Abamectin",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Azathioprine",
   "cas": "446-86-6",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1996-09-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Azathioprine",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Barbiturates",
   "cas": "",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1992-10-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Barbiturate",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "BBP; benzyl butyl phthalate e",
   "cas": "85-68-7",
   "ec": "201-622-7",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360Df"
     ],
     "developmental_specific": true,
     "atp": "CLP00",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "607-430-00-3"
    },
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "authoritative body",
     "listed": "2005-12-02",
     "madl_ug_day": "1200 (oral)",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "clp": "presumed",
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    },
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Benzyl_butyl_phthalate",
   "level": "known",
   "source_codes": [
    "clp",
    "p65"
   ]
  },
  {
   "name": "Beclomethasone dipropionate",
   "cas": "5534-09-8",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1998-05-15",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Beclometasone",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "benomyl (ISO); methyl 1-(butylcarbamoyl)benzimidazol-2-ylcarbamate",
   "cas": "17804-35-2",
   "ec": "241-775-7",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360FD"
     ],
     "developmental_specific": true,
     "atp": "CLP00",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "613-049-00-3"
    },
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental, male",
     "mechanism": "State's Qualified Experts",
     "listed": "1991-07-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "clp": "presumed",
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    },
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Benomyl",
   "level": "known",
   "source_codes": [
    "clp",
    "p65"
   ]
  },
  {
   "name": "Benzene",
   "cas": "71-43-2",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental, male",
     "mechanism": "State's Qualified Experts",
     "listed": "1997-12-26",
     "madl_ug_day": "24 (oral)\n49 (inhalation)",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Benzene",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Benzodiazepines",
   "cas": "",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1992-10-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Benzodiazepine",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Benzphetamine hydrochloride",
   "cas": "5411-22-3",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1990-04-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Benzphetamine",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Bevacizumab",
   "cas": "216974-75-3",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental, female",
     "mechanism": "formally required to be labelled or identified",
     "listed": "2019-03-08",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Bevacizumab",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "bis(2-ethylhexyl) phthalate; di-(2-ethylhexyl) phthalate; DEHP",
   "cas": "117-81-7",
   "ec": "204-211-0",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360FD"
     ],
     "developmental_specific": true,
     "atp": "CLP00",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "607-317-00-9"
    },
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental, male",
     "mechanism": "authoritative body",
     "listed": "2003-10-24",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "clp": "presumed",
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    },
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Bis(2-ethylhexyl)_phthalate",
   "level": "known",
   "source_codes": [
    "clp",
    "p65"
   ]
  },
  {
   "name": "Bischloroethyl nitrosourea (BCNU) (Carmustine)",
   "cas": "154-93-8",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1990-07-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Carmustine",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Bisphenol A (BPA)",
   "cas": "80-05-7",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "authoritative body",
     "listed": "2020-12-18",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Bisphenol_A",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "brodifacoum (ISO); 4-hydroxy-3-(3-(4′-bromo-4-biphenylyl)-1,2,3,4-tetrahydro-1-naphthyl)coumarin",
   "cas": "56073-10-0",
   "ec": "259-980-5",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1A",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "ATP09",
     "applies_from": "2018-03-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32016R1179",
     "index": "607-172-00-1"
    }
   ],
   "status": {
    "clp": "known"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Brodifacoum",
   "level": "known",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "Bromacil lithium salt",
   "cas": "53404-19-6",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "authoritative body",
     "listed": "1999-05-18",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Bromacil",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "bromoxynil octanoate (ISO); 2,6-dibromo-4-cyanophenyl octanoate",
   "cas": "1689-99-2",
   "ec": "216-885-3",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361d"
     ],
     "developmental_specific": true,
     "atp": "CLP00",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "608-017-00-0"
    },
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "authoritative body",
     "listed": "1999-05-18",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "clp": "suspected",
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    },
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Bromoxynil_octanoate",
   "level": "known",
   "source_codes": [
    "clp",
    "p65"
   ]
  },
  {
   "name": "Butabarbital sodium",
   "cas": "143-81-7",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1992-10-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Butabarbital_sodium",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Cadmium",
   "cas": "",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental, male",
     "mechanism": "State's Qualified Experts",
     "listed": "1997-05-01",
     "madl_ug_day": "4.1 (oral)",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Cadmium",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Cannabis (marijuana) smoke",
   "cas": "",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "State's Qualified Experts",
     "listed": "2020-01-03",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Cannabis",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Carbamazepine",
   "cas": "298-46-4",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1999-01-29",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Carbamazepine",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Carbaryl [Basis for listing changed effective December 27, 2013]",
   "cas": "63-25-2",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental, female, male",
     "mechanism": "authoritative body",
     "listed": "2009-08-07",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Carbaryl",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "carbon disulphide",
   "cas": "75-15-0",
   "ec": "200-843-6",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361fd"
     ],
     "developmental_specific": true,
     "atp": "CLP00",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "006-003-00-3"
    },
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental, female, male",
     "mechanism": "State's Qualified Experts",
     "listed": "1989-07-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "clp": "suspected",
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    },
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Carbon_disulfide",
   "level": "known",
   "source_codes": [
    "clp",
    "p65"
   ]
  },
  {
   "name": "carbon monoxide",
   "cas": "630-08-0",
   "ec": "211-128-3",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1A",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "CLP00",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "006-001-00-2"
    },
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "State's Qualified Experts",
     "listed": "1989-07-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "clp": "known",
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    },
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Carbon_monoxide",
   "level": "known",
   "source_codes": [
    "clp",
    "p65"
   ]
  },
  {
   "name": "Carboplatin",
   "cas": "41575-94-4",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1990-07-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Carboplatin",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Chenodiol",
   "cas": "474-25-9",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1990-04-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Chenodeoxycholic_acid",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Chlorambucil",
   "cas": "305-03-3",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "State's Qualified Experts",
     "listed": "1989-01-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Chlorambucil",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Chlorcyclizine hydrochloride",
   "cas": "1620-21-9",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1987-07-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Chlorcyclizine",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Chlordecone (Kepone)",
   "cas": "143-50-0",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "State's Qualified Experts",
     "listed": "1989-01-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Chlordecone",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Chlordiazepoxide",
   "cas": "58-25-3",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1992-01-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Chlordiazepoxide",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Chlordiazepoxide hydrochloride",
   "cas": "438-41-5",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1992-01-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Chlordiazepoxide",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "chloroform; trichloromethane",
   "cas": "67-66-3",
   "ec": "200-663-8",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361d"
     ],
     "developmental_specific": true,
     "atp": "ATP05",
     "applies_from": "2015-01-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32013R0944",
     "index": "602-006-00-4"
    },
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "State's Qualified Experts",
     "listed": "2009-08-07",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "clp": "suspected",
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    },
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Chloroform",
   "level": "known",
   "source_codes": [
    "clp",
    "p65"
   ]
  },
  {
   "name": "Chlorpyrifos",
   "cas": "2921-88-2",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "State's Qualified Experts",
     "listed": "2017-12-15",
     "madl_ug_day": "0.58 (oral and inhalation) 7.2 (dermal)",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Chlorpyrifos",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Chlorsulfuron Delisted June 6, 2014 [Click here for the basis for delisting]",
   "cas": "64902-72-3",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental, female, male",
     "mechanism": "authoritative body",
     "listed": "1999-05-14",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Chlorsulfuron",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Chromium (hexavalent compounds)",
   "cas": "",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental, female, male",
     "mechanism": "State's Qualified Experts",
     "listed": "2008-12-19",
     "madl_ug_day": "8.2 (oral)",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Chromium",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Cidofovir",
   "cas": "113852-37-2",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "cancer, developmental, female, male",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1999-01-29",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Cidofovir",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Cladribine",
   "cas": "4291-63-8",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1996-09-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Cladribine",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Clarithromycin",
   "cas": "81103-11-9",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1997-05-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Clarithromycin",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Clobetasol propionate",
   "cas": "25122-46-7",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental, female",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1998-05-15",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Clobetasol_propionate",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Clomiphene citrate",
   "cas": "50-41-9",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1990-04-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Clomiphene_citrate",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Clorazepate dipotassium",
   "cas": "57109-90-7",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1992-10-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Clorazepate",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Cocaine",
   "cas": "50-36-2",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental, female",
     "mechanism": "State's Qualified Experts",
     "listed": "1989-07-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Cocaine",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Codeine phosphate",
   "cas": "52-28-8",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1998-05-15",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Codeine_phosphate",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Colchicine",
   "cas": "64-86-8",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental, male",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1992-10-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Colchicine",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Conjugated estrogens",
   "cas": "",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1990-04-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Conjugated_estrogens",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Cyanazine",
   "cas": "21725-46-2",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1990-04-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Cyanazine",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Cycloate",
   "cas": "1134-23-2",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "authoritative body",
     "listed": "1999-03-19",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": null,
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "cycloheximide (ISO); 4-{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione",
   "cas": "66-81-9",
   "ec": "200-636-0",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "CLP00",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "613-140-00-8"
    },
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1989-01-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "clp": "presumed",
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    },
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Cycloheximide",
   "level": "known",
   "source_codes": [
    "clp",
    "p65"
   ]
  },
  {
   "name": "Cyclophosphamide (anhydrous)",
   "cas": "50-18-0",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental, female, male",
     "mechanism": "SQE - developmental    FR - female, male",
     "listed": "1989-01-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Cyclophosphamide",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Cyclophosphamide (hydrated)",
   "cas": "6055-19-2",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental, female, male",
     "mechanism": "SQE - developmental     FR - female, male",
     "listed": "1989-01-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Cyclophosphamide",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Cyhexatin",
   "cas": "13121-70-5",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1989-01-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Cyhexatin",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Cytarabine",
   "cas": "147-94-4",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "State's Qualified Experts",
     "listed": "1989-01-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Cytarabine",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Dacarbazine",
   "cas": "4342-03-4",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1999-01-29",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Dacarbazine",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Danazol",
   "cas": "17230-88-5",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1990-04-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Danazol",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Daunorubicin hydrochloride",
   "cas": "23541-50-6",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1990-07-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Daunorubicin",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Demeclocycline hydrochloride (internal use)",
   "cas": "64-73-3",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1992-01-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Demeclocycline",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Des-ethyl atrazine (DEA)",
   "cas": "6190-65-4",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental, female",
     "mechanism": "authoritative body",
     "listed": "2016-07-15",
     "madl_ug_day": "100 (oral)",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": null,
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Des-isopropyl atrazine (DIA)",
   "cas": "1007-28-9",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental, female",
     "mechanism": "authoritative body",
     "listed": "2016-07-15",
     "madl_ug_day": "100 (oral)",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": null,
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Di-isodecyl phthalate (DIDP)",
   "cas": "",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "authoritative body",
     "listed": "2007-04-20",
     "madl_ug_day": "2200",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Diisodecyl_phthalate",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Diazepam",
   "cas": "439-14-5",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1992-01-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Diazepam",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Diazoxide",
   "cas": "364-98-7",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "2001-02-27",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Diazoxide",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "dibutyl phthalate; DBP",
   "cas": "84-74-2",
   "ec": "201-557-4",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360Df"
     ],
     "developmental_specific": true,
     "atp": "CLP00",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "607-318-00-4"
    },
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental, female, male",
     "mechanism": "authoritative body",
     "listed": "2005-12-02",
     "madl_ug_day": "8.6999999999999993",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "clp": "presumed",
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    },
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Dibutyl_phthalate",
   "level": "known",
   "source_codes": [
    "clp",
    "p65"
   ]
  },
  {
   "name": "Dichloroacetic acid",
   "cas": "79-43-6",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental, male",
     "mechanism": "authoritative body",
     "listed": "2009-08-07",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Dichloroacetic_acid",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Dichlorophene",
   "cas": "97-23-4",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "authoritative body",
     "listed": "1999-04-27",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Dichlorophen",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Dichlorphenamide",
   "cas": "120-97-8",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "2001-02-27",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Diclofenamide",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Diclofop methyl",
   "cas": "51338-27-3",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "authoritative body",
     "listed": "1999-03-05",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": null,
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Dicumarol",
   "cas": "66-76-2",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1992-10-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Dicoumarol",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Diethylstilbestrol (DES)",
   "cas": "56-53-1",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1987-07-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Diethylstilbestrol",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Diflunisal",
   "cas": "22494-42-4",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental, female",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1999-01-29",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Diflunisal",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Dihydroergotamine mesylate",
   "cas": "6190-39-2",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1997-05-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Dihydroergotamine",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Diltiazem hydrochloride",
   "cas": "33286-22-5",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "2001-02-27",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Diltiazem_hydrochloride",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "dinitrogen oxide",
   "cas": "10024-97-2",
   "ec": "233-032-0",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360Df"
     ],
     "developmental_specific": true,
     "atp": "ATP23",
     "applies_from": "2027-02-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32025R1222",
     "index": "007-031-00-9"
    },
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental, female",
     "mechanism": "authoritative body",
     "listed": "2008-08-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "clp": "presumed",
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    },
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Nitrous_oxide",
   "level": "known",
   "source_codes": [
    "clp",
    "p65"
   ]
  },
  {
   "name": "dinocap (ISO); (RS)-2,6-dinitro-4-octylphenyl crotonates and (RS)-2,4-dinitro-6-octylphenyl crotonates in which ‘octyl’ is a reaction mass of 1-methylheptyl, 1-ethylhexyl and 1-propylpentyl groups",
   "cas": "39300-45-3",
   "ec": "254-408-0",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "ATP01",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32009R0790",
     "index": "609-023-00-6"
    },
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1990-04-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "clp": "presumed",
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    },
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": null,
   "level": "known",
   "source_codes": [
    "clp",
    "p65"
   ]
  },
  {
   "name": "dinoseb(ISO); 6-sec-butyl-2,4-dinitrophenol",
   "cas": "88-85-7",
   "ec": "201-861-7",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360Df"
     ],
     "developmental_specific": true,
     "atp": "CLP00",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "609-025-00-7"
    },
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental, male",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1989-01-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "clp": "presumed",
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    },
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Dinoseb",
   "level": "known",
   "source_codes": [
    "clp",
    "p65"
   ]
  },
  {
   "name": "Diphenylhydantoin (Phenytoin)",
   "cas": "57-41-0",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "State's Qualified Experts",
     "listed": "1987-07-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Phenytoin",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Disodium cyanodithioimidocarbonate",
   "cas": "138-93-2",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "authoritative body",
     "listed": "1999-03-30",
     "madl_ug_day": "56 (oral)\n170 (oral) as 32% pesticidal formulation",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": null,
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Doxorubicin hydrochloride (Adriamycin)",
   "cas": "25316-40-9",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental, male",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1999-01-29",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Doxorubicin_hydrochloride",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Doxycycline (internal use)",
   "cas": "564-25-0",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1990-07-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Doxycycline",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Doxycycline calcium (internal use)",
   "cas": "94088-85-4",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1992-01-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Doxycycline",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Doxycycline hyclate (internal use)",
   "cas": "24390-14-5",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1991-10-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Doxycycline",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Doxycycline monohydrate (internal use)",
   "cas": "17086-28-1",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1991-10-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Doxycycline",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Endrin",
   "cas": "72-20-8",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "authoritative body",
     "listed": "1998-05-15",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Endrin",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Environmental tobacco smoke (ETS)",
   "cas": "",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "State's Qualified Experts",
     "listed": "2006-06-09",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Passive_smoking",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Ergotamine tartrate",
   "cas": "379-79-3",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1990-04-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Ergotamine_tartrate",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Estropipate",
   "cas": "7280-37-7",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "cancer, developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1997-08-26",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Estropipate",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Ethionamide",
   "cas": "536-33-4",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1997-08-26",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Ethionamide",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Ethyl alcohol in alcoholic beverages",
   "cas": "",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "State's Qualified Experts",
     "listed": "1987-10-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": null,
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Ethyl dipropylthiocarbamate",
   "cas": "759-94-4",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "authoritative body",
     "listed": "1999-04-27",
     "madl_ug_day": "700 (oral and inhalation)\n6700 (dermal)",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/EPTC_(herbicide)",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Ethylene dibromide",
   "cas": "106-93-4",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental, male",
     "mechanism": "authoritative body",
     "listed": "1998-05-15",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/1,2-Dibromoethane",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Ethylene glycol (ingested)",
   "cas": "107-21-1",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "authoritative body",
     "listed": "2015-06-19",
     "madl_ug_day": "8700 (oral)",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Ethylene_glycol",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "ethylene oxide; oxirane",
   "cas": "75-21-8",
   "ec": "200-849-9",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360Fd"
     ],
     "developmental_specific": true,
     "atp": "ATP14",
     "applies_from": "2021-09-09",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32020R0217",
     "index": "603-023-00-X"
    },
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental, male",
     "mechanism": "formally required to be labelled or identified",
     "listed": "2009-08-07",
     "madl_ug_day": "20",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "clp": "presumed",
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    },
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Ethylene_oxide",
   "level": "known",
   "source_codes": [
    "clp",
    "p65"
   ]
  },
  {
   "name": "ethylene thiourea; imidazolidine-2-thione; 2-imidazoline-2-thiol",
   "cas": "96-45-7",
   "ec": "202-506-9",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "CLP00",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "613-039-00-9"
    },
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "State's Qualified Experts",
     "listed": "1993-01-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "clp": "presumed",
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    },
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Ethylene_thiourea",
   "level": "known",
   "source_codes": [
    "clp",
    "p65"
   ]
  },
  {
   "name": "Etodolac",
   "cas": "41340-25-4",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental, female",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1999-08-20",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Etodolac",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Etoposide",
   "cas": "33419-42-0",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1990-07-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Etoposide",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Etretinate",
   "cas": "54350-48-0",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "State's Qualified Experts",
     "listed": "1987-07-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Etretinate",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Fenoxaprop ethyl",
   "cas": "66441-23-4",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "authoritative body",
     "listed": "1999-03-26",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Fenoxaprop_ethyl",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "fentin hydroxide (ISO); triphenyltin hydroxide",
   "cas": "76-87-9",
   "ec": "200-990-6",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361d"
     ],
     "developmental_specific": true,
     "atp": "ATP01",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32009R0790",
     "index": "050-004-00-1"
    },
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "authoritative body",
     "listed": "2002-03-18",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "clp": "suspected",
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    },
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Triphenyltin_hydroxide",
   "level": "known",
   "source_codes": [
    "clp",
    "p65"
   ]
  },
  {
   "name": "Filgrastim",
   "cas": "121181-53-1",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "2001-02-27",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Filgrastim",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Fingolimod",
   "cas": "162359-55-9",
   "ec": "",
   "kind": "medicine",
   "sources": [
    {
     "label": "EMA: pregnancy prevention programme or contraindication for teratogenicity",
     "code": "ema",
     "note": "Multiple sclerosis medicine (Gilenya): EMA measures of 2019 on the risk of congenital malformations.",
     "url": "https://www.ema.europa.eu/documents/press-release/updated-restrictions-gilenya-multiple-sclerosis-medicine-not-be-used-pregnancy_en.pdf",
     "url_status": 200
    }
   ],
   "status": {
    "ema": "known"
   },
   "jurisdictions": {
    "EU / EEA": "Authorised; contraindicated in pregnancy and in women of childbearing potential not using effective contraception."
   },
   "wiki": "https://en.wikipedia.org/wiki/Fingolimod",
   "level": "known",
   "source_codes": [
    "ema"
   ]
  },
  {
   "name": "fluazifop-butyl (ISO); butyl (RS)-2-[4-(5-trifluoromethyl-2-pyridyloxy)phenoxy]propionate",
   "cas": "69806-50-4",
   "ec": "274-125-6",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "CLP00",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "607-304-00-8"
    },
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "authoritative body",
     "listed": "1998-11-06",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "clp": "presumed",
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    },
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": null,
   "level": "known",
   "source_codes": [
    "clp",
    "p65"
   ]
  },
  {
   "name": "Flunisolide",
   "cas": "3385-03-3",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental, female",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1998-05-15",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Flunisolide",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Fluorouracil",
   "cas": "51-21-8",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "State's Qualified Experts",
     "listed": "1989-01-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Fluorouracil",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Fluoxymesterone",
   "cas": "76-43-7",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1990-04-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Fluoxymesterone",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Flurazepam hydrochloride",
   "cas": "1172-18-5",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1992-10-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Flurazepam",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Flurbiprofen",
   "cas": "5104-49-4",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental, female",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1999-08-20",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Flurbiprofen",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Flutamide",
   "cas": "13311-84-7",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1990-07-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Flutamide",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Fluticasone propionate",
   "cas": "80474-14-2",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1998-05-15",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Fluticasone_propionate",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Fluvalinate",
   "cas": "69409-94-5",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "authoritative body",
     "listed": "1998-11-06",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Fluvalinate",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Ganciclovir",
   "cas": "82410-32-0",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "cancer, developmental, male",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1997-08-26",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Ganciclovir",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Ganciclovir sodium",
   "cas": "107910-75-8",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental, male",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1997-08-26",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Ganciclovir_sodium",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Goserelin acetate",
   "cas": "65807-02-5",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental, female, male",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1997-08-26",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Goserelin",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Halazepam",
   "cas": "23092-17-3",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1990-07-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Halazepam",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Halobetasol propionate",
   "cas": "66852-54-8",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1999-08-20",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Ulobetasol_propionate",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Haloperidol",
   "cas": "52-86-8",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental, female",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1999-01-29",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Haloperidol",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Halothane",
   "cas": "151-67-7",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1996-09-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Halothane",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Heptachlor",
   "cas": "76-44-8",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "authoritative body",
     "listed": "1999-08-20",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Heptachlor",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Hexachlorobenzene",
   "cas": "118-74-1",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "State's Qualified Experts",
     "listed": "1989-01-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Hexachlorobenzene",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Hexafluoroacetone [Basis for listing changed effective June 6, 2014]",
   "cas": "684-16-2",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental, male",
     "mechanism": "LC SQE",
     "listed": "2008-08-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Hexafluoroacetone",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Histrelin acetate",
   "cas": "",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1998-05-15",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Histrelin",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Hydramethylnon",
   "cas": "67485-29-4",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental, male",
     "mechanism": "authoritative body",
     "listed": "1999-03-05",
     "madl_ug_day": "120 (oral)",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Hydramethylnon",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Hydroxyurea",
   "cas": "127-07-1",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1997-05-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Hydroxycarbamide",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Idarubicin hydrochloride",
   "cas": "57852-57-0",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental, male",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1999-08-20",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Idarubicin",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Ifosfamide",
   "cas": "3778-73-2",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1990-07-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Ifosfamide",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Iodine-131",
   "cas": "10043-66-0",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "State's Qualified Experts",
     "listed": "1989-01-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Iodine-131",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Isotretinoin",
   "cas": "4759-48-2",
   "ec": "",
   "kind": "medicine",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "State's Qualified Experts",
     "listed": "1987-07-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    },
    {
     "label": "EMA: pregnancy prevention programme or contraindication for teratogenicity",
     "code": "ema",
     "note": "Oral retinoids: EMA referral of 2018 harmonised the pregnancy prevention programme across the EU.",
     "url": "https://www.ema.europa.eu/en/medicines/human/referrals/retinoid-containing-medicinal-products",
     "url_status": 200
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity",
    "ema": "known"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    },
    "EU / EEA": "Authorised with a pregnancy prevention programme; contraindicated in pregnancy.",
    "USA": "Isotretinoin authorised under the iPLEDGE REMS programme."
   },
   "wiki": "https://en.wikipedia.org/wiki/Isotretinoin",
   "level": "known",
   "source_codes": [
    "ema",
    "p65"
   ]
  },
  {
   "name": "lead 2,4,6-trinitro-m-phenylene dioxide; lead 2,4,6-trinitroresorcinoxide; lead styphnate",
   "cas": "15245-44-0",
   "ec": "239-290-0",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1A",
     "statements": [
      "H360Df"
     ],
     "developmental_specific": true,
     "atp": "CLP00",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "609-019-00-4"
    },
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1A",
     "statements": [
      "H360Df"
     ],
     "developmental_specific": true,
     "atp": "CLP00",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "609-019-01-1"
    }
   ],
   "status": {
    "clp": "known"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Lead_styphnate",
   "level": "known",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "Lead [Basis for listing changed effective November 22, 2013]",
   "cas": "",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental, female, male",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1987-02-27",
     "madl_ug_day": "0.5",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Lead_[Basis_for_listing_changed_effective_November_22,_2013]",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "lead acetate, basic",
   "cas": "1335-32-6",
   "ec": "215-630-3",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1A",
     "statements": [
      "H360Df"
     ],
     "developmental_specific": true,
     "atp": "CLP00",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "082-007-00-9"
    }
   ],
   "status": {
    "clp": "known"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Basic_lead_acetate",
   "level": "known",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "lead alkyls",
   "cas": "",
   "ec": "-",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1A",
     "statements": [
      "H360Df"
     ],
     "developmental_specific": true,
     "atp": "CLP00",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "082-002-00-1"
    }
   ],
   "status": {
    "clp": "known"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": null,
   "level": "known",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "lead chromate",
   "cas": "7758-97-6",
   "ec": "231-846-0",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1A",
     "statements": [
      "H360Df"
     ],
     "developmental_specific": true,
     "atp": "ATP01",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32009R0790",
     "index": "082-004-00-2"
    }
   ],
   "status": {
    "clp": "known"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Lead(II)_chromate",
   "level": "known",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "lead chromate molybdate sulfate red; C.I. Pigment Red 104; [This substance is identified in the Colour Index by Colour Index Constitution Number, C.I. 77605.]",
   "cas": "12656-85-8",
   "ec": "235-759-9",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1A",
     "statements": [
      "H360Df"
     ],
     "developmental_specific": true,
     "atp": "ATP01",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32009R0790",
     "index": "082-010-00-5"
    }
   ],
   "status": {
    "clp": "known"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": null,
   "level": "known",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "lead compounds with the exception of those specified elsewhere in this Annex",
   "cas": "",
   "ec": "-",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1A",
     "statements": [
      "H360Df"
     ],
     "developmental_specific": true,
     "atp": "CLP00",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "082-001-00-6"
    }
   ],
   "status": {
    "clp": "known"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": null,
   "level": "known",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "lead di(acetate)",
   "cas": "301-04-2",
   "ec": "206-104-4",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1A",
     "statements": [
      "H360Df"
     ],
     "developmental_specific": true,
     "atp": "CLP00",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "082-005-00-8"
    }
   ],
   "status": {
    "clp": "known"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Lead(II)_acetate",
   "level": "known",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "lead diazide; lead azide",
   "cas": "13424-46-9",
   "ec": "236-542-1",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1A",
     "statements": [
      "H360Df"
     ],
     "developmental_specific": true,
     "atp": "CLP00",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "082-003-00-7"
    },
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1A",
     "statements": [
      "H360Df"
     ],
     "developmental_specific": true,
     "atp": "CLP00",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "082-003-01-4"
    }
   ],
   "status": {
    "clp": "known"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Lead(II)_azide",
   "level": "known",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "lead hexafluorosilicate",
   "cas": "25808-74-6",
   "ec": "247-278-1",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
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   },
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  },
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   "name": "lead hydrogen arsenate",
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     "index": "082-011-00-0"
    }
   ],
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    "clp": "known"
   },
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     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
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    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Lead_hydrogen_arsenate",
   "level": "known",
   "source_codes": [
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  },
  {
   "name": "lead powder; [particle diameter < 1 mm]",
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     "index": "082-013-00-1"
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   ],
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    "clp": "known"
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     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
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    }
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   "wiki": "https://en.wikipedia.org/wiki/Lead",
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  },
  {
   "name": "lead sulfochromate yellow; C.I. Pigment Yellow 34; [This substance is identified in the Colour Index by Colour Index Constitution Number, C.I. 77603.]",
   "cas": "1344-37-2",
   "ec": "215-693-7",
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    {
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     "code": "clp",
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     "atp": "ATP01",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32009R0790",
     "index": "082-009-00-X"
    }
   ],
   "status": {
    "clp": "known"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
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     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
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   },
   "wiki": null,
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  },
  {
   "name": "lead(II) methanesulphonate",
   "cas": "17570-76-2",
   "ec": "401-750-5",
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    {
     "label": "EU harmonised classification (CLP Annex VI)",
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     "index": "082-008-00-4"
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   ],
   "status": {
    "clp": "known"
   },
   "jurisdictions": {
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     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": null,
   "level": "known",
   "source_codes": [
    "clp"
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  },
  {
   "name": "Leuprolide acetate",
   "cas": "74381-53-6",
   "ec": "",
   "kind": "chemical",
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     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental, female, male",
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     "listed": "1997-08-26",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Leuprorelin",
   "level": "known",
   "source_codes": [
    "p65"
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  },
  {
   "name": "Levodopa",
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   "ec": "",
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     "listed": "1999-01-29",
     "madl_ug_day": "",
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   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
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     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
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   },
   "wiki": "https://en.wikipedia.org/wiki/L-DOPA",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "linuron (ISO); 3-(3,4-dichlorophenyl)-1-methoxy-1-methylurea",
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   "ec": "206-356-5",
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     "code": "clp",
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     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "006-021-00-1"
    },
    {
     "label": "California Proposition 65 (developmental toxicant)",
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     "listed": "1999-03-19",
     "madl_ug_day": "460",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
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   ],
   "status": {
    "clp": "presumed",
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
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     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
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   },
   "wiki": "https://en.wikipedia.org/wiki/Linuron",
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  },
  {
   "name": "Lithium carbonate",
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     "madl_ug_day": "",
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   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
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     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
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   },
   "wiki": "https://en.wikipedia.org/wiki/Lithium_carbonate",
   "level": "known",
   "source_codes": [
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  },
  {
   "name": "Lithium citrate",
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     "label": "California Proposition 65 (developmental toxicant)",
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     "madl_ug_day": "",
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   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
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   },
   "wiki": "https://en.wikipedia.org/wiki/Lithium_citrate",
   "level": "known",
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  },
  {
   "name": "Lorazepam",
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     "label": "California Proposition 65 (developmental toxicant)",
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     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
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   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
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   "jurisdictions": {
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    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Lorazepam",
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   "source_codes": [
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  {
   "name": "Lovastatin",
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   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
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   },
   "wiki": "https://en.wikipedia.org/wiki/Lovastatin",
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   "source_codes": [
    "p65"
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  },
  {
   "name": "Mebendazole",
   "cas": "31431-39-7",
   "ec": "",
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    {
     "label": "California Proposition 65 (developmental toxicant)",
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     "listed": "1999-08-20",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Mebendazole",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Medroxyprogesterone acetate",
   "cas": "71-58-9",
   "ec": "",
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    {
     "label": "California Proposition 65 (developmental toxicant)",
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     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
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   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Medroxyprogesterone_acetate",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Megestrol acetate",
   "cas": "595-33-5",
   "ec": "",
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    {
     "label": "California Proposition 65 (developmental toxicant)",
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     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
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   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Megestrol_acetate",
   "level": "known",
   "source_codes": [
    "p65"
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  },
  {
   "name": "Melphalan",
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   "ec": "",
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    {
     "label": "California Proposition 65 (developmental toxicant)",
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     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
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   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Melphalan",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Menotropins",
   "cas": "9002-68-0",
   "ec": "",
   "kind": "chemical",
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    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
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     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
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   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Follicle-stimulating_hormone",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Meprobamate",
   "cas": "57-53-4",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
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     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Meprobamate",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Mercaptopurine",
   "cas": "6112-76-1",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1990-07-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Mercaptopurine",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Mercury and mercury compounds",
   "cas": "",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "authoritative body",
     "listed": "1990-07-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": null,
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Methacycline hydrochloride",
   "cas": "3963-95-9",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1991-01-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Metacycline",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Metham sodium",
   "cas": "137-42-8",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "authoritative body",
     "listed": "1998-05-15",
     "madl_ug_day": "290",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Metam_sodium",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Methanol",
   "cas": "67-56-1",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "authoritative body",
     "listed": "2012-03-16",
     "madl_ug_day": "47,000 (inhalation)  \n23,000 (oral)",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Methanol",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Methazole",
   "cas": "20354-26-1",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "authoritative body",
     "listed": "1999-12-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Methazole",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Methimazole",
   "cas": "60-56-0",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1990-07-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Thiamazole",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Methotrexate",
   "cas": "59-05-2",
   "ec": "",
   "kind": "medicine",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "State's Qualified Experts",
     "listed": "1989-01-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    },
    {
     "label": "EMA: pregnancy prevention programme or contraindication for teratogenicity",
     "code": "ema",
     "note": "Folate antagonist: EMA referral of 2018 harmonised warnings; contraindicated in pregnancy for non-oncology use.",
     "url": "https://www.ema.europa.eu/en/medicines/human/referrals/methotrexate-containing-medicinal-products",
     "url_status": 200
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity",
    "ema": "known"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    },
    "EU / EEA": "Authorised; contraindicated in pregnancy for non-oncology indications, with contraception requirements."
   },
   "wiki": "https://en.wikipedia.org/wiki/Methotrexate",
   "level": "known",
   "source_codes": [
    "ema",
    "p65"
   ]
  },
  {
   "name": "Methotrexate sodium",
   "cas": "15475-56-6",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1990-04-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Methotrexate_sodium",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Methyl bromide, as a structural fumigant",
   "cas": "74-83-9",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1993-01-01",
     "madl_ug_day": "810 (inhalation)",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Bromomethane",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Methyl chloride",
   "cas": "74-87-3",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "authoritative body",
     "listed": "2000-03-10",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Chloromethane",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Methyl isobutyl ketone (MIBK)",
   "cas": "108-10-1",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "authoritative body",
     "listed": "2014-03-28",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Methyl_isobutyl_ketone",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "methyl isocyanate",
   "cas": "624-83-9",
   "ec": "210-866-3",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361d"
     ],
     "developmental_specific": true,
     "atp": "ATP01",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32009R0790",
     "index": "615-001-00-7"
    },
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental, female",
     "mechanism": "State's Qualified Experts",
     "listed": "2010-11-12",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "clp": "suspected",
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    },
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Methyl_isocyanate",
   "level": "known",
   "source_codes": [
    "clp",
    "p65"
   ]
  },
  {
   "name": "Methyl isopropyl ketone Delisted April 4, 2014 [Click for the basis for delisting]",
   "cas": "563-80-4",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "Labor Code",
     "listed": "2012-02-17",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Methyl_isopropyl_ketone",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Methyl mercury",
   "cas": "",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "State's Qualified Experts",
     "listed": "1987-07-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Methylmercury",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Methyl-n-butyl ketone",
   "cas": "591-78-6",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "State's Qualified Experts",
     "listed": "2015-12-04",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/2-Hexanone",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "methylmercuric chloride",
   "cas": "115-09-3",
   "ec": "204-064-2",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1A",
     "statements": [
      "H360Df"
     ],
     "developmental_specific": true,
     "atp": "ATP14",
     "applies_from": "2021-09-09",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32020R0217",
     "index": "080-012-00-0"
    }
   ],
   "status": {
    "clp": "known"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": null,
   "level": "known",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "Methyltestosterone",
   "cas": "58-18-4",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1990-04-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Methyltestosterone",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Metiram",
   "cas": "9006-42-2",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "authoritative body",
     "listed": "1999-03-30",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": null,
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Midazolam hydrochloride",
   "cas": "59467-96-8",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1990-07-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Midazolam",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Minocycline hydrochloride (internal use)",
   "cas": "13614-98-7",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1992-01-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Minocycline",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Misoprostol",
   "cas": "59122-46-2",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1990-04-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Misoprostol",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Mitoxantrone hydrochloride",
   "cas": "70476-82-3",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1990-07-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Mitoxantrone",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Molinate",
   "cas": "2212-67-1",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental, female, male",
     "mechanism": "authoritative body",
     "listed": "2009-12-11",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": null,
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "myclobutanil(ISO); 2-(4-chlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)hexanenitrile",
   "cas": "88671-89-0",
   "ec": "-",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361d"
     ],
     "developmental_specific": true,
     "atp": "CLP00",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "613-134-00-5"
    },
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental, male",
     "mechanism": "authoritative body",
     "listed": "1999-04-16",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "clp": "suspected",
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    },
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Myclobutanil",
   "level": "known",
   "source_codes": [
    "clp",
    "p65"
   ]
  },
  {
   "name": "Mycophenolate mofetil and mycophenolic acid",
   "cas": "128794-94-5",
   "ec": "",
   "kind": "medicine",
   "sources": [
    {
     "label": "EMA: pregnancy prevention programme or contraindication for teratogenicity",
     "code": "ema",
     "note": "Immunosuppressant: EMA referral of 2015 imposed pregnancy prevention measures.",
     "url": "https://www.ema.europa.eu/en/documents/press-release/ema-recommends-additional-measures-prevent-use-mycophenolate-pregnancy_en.pdf",
     "url_status": 200
    }
   ],
   "status": {
    "ema": "known"
   },
   "jurisdictions": {
    "EU / EEA": "Authorised with pregnancy prevention measures; contraindicated in pregnancy unless no suitable alternative.",
    "USA": "Authorised under an FDA REMS programme."
   },
   "wiki": null,
   "level": "known",
   "source_codes": [
    "ema"
   ]
  },
  {
   "name": "N,N-dimethylacetamide",
   "cas": "127-19-5",
   "ec": "204-826-4",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "ATP09",
     "applies_from": "2018-03-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32016R1179",
     "index": "616-011-00-4"
    },
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental, male",
     "mechanism": "State's Qualified Experts",
     "listed": "2010-05-21",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "clp": "presumed",
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    },
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Dimethylacetamide",
   "level": "known",
   "source_codes": [
    "clp",
    "p65"
   ]
  },
  {
   "name": "N-methyl-2-pyrrolidone; 1-methyl-2-pyrrolidone",
   "cas": "872-50-4",
   "ec": "212-828-1",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "ATP09",
     "applies_from": "2018-03-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32016R1179",
     "index": "606-021-00-7"
    },
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "authoritative body",
     "listed": "2001-06-15",
     "madl_ug_day": "3200 (inhalation)\n17000 (dermal)",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "clp": "presumed",
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    },
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/N-Methyl-2-pyrrolidone",
   "level": "known",
   "source_codes": [
    "clp",
    "p65"
   ]
  },
  {
   "name": "Nabam",
   "cas": "142-59-6",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "authoritative body",
     "listed": "1999-03-30",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": null,
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Nafarelin acetate",
   "cas": "86220-42-0",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1990-04-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Nafarelin",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Neomycin sulfate (internal use)",
   "cas": "1405-10-3",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1992-10-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Neomycin",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Netilmicin sulfate",
   "cas": "56391-57-2",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1990-07-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Netilmicin",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Nickel (soluble compounds)",
   "cas": "",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental, male",
     "mechanism": "State's Qualified Experts",
     "listed": "2018-10-26",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Nickel",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Nicotine",
   "cas": "54-11-5",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1990-04-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Nicotine",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Nifedipine",
   "cas": "21829-25-4",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental, female, male",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1999-01-29",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Nifedipine",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Nimodipine",
   "cas": "66085-59-4",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "2001-04-24",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Nimodipine",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Nitrapyrin",
   "cas": "1929-82-4",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "authoritative body",
     "listed": "1999-03-30",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Nitrapyrin",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Nitrogen mustard (Mechlorethamine)",
   "cas": "51-75-2",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "State's Qualified Experts",
     "listed": "1989-01-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Chlormethine",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Nitrogen mustard hydrochloride (Mechlorethamine hydrochloride)",
   "cas": "55-86-7",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1990-07-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Nitrogen_mustard",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Norethisterone (Norethindrone)",
   "cas": "68-22-4",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1990-04-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Norethisterone",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Norethisterone (Norethindrone) /Ethinyl estradiol",
   "cas": "",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1990-04-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Norethisterone",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Norethisterone (Norethindrone) /Mestranol",
   "cas": "",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1990-04-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Norethisterone",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Norethisterone acetate (Norethindrone acetate)",
   "cas": "51-98-9",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1991-10-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Norethisterone_acetate",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Norgestrel",
   "cas": "6533-00-2",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1990-04-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Norgestrel",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "o,p'-DDT",
   "cas": "789-02-6",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental, female, male",
     "mechanism": "authoritative body",
     "listed": "1998-05-15",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/O,p%27-DDT",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Oxadiazon",
   "cas": "19666-30-9",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "authoritative body",
     "listed": "1998-05-15",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": null,
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Oxazepam",
   "cas": "604-75-1",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1992-10-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Oxazepam",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Oxymetholone",
   "cas": "434-07-1",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1997-05-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Oxymetholone",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Oxytetracycline (internal use)",
   "cas": "79-57-2",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1991-01-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Oxytetracycline",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Oxytetracycline hydrochloride (internal use)",
   "cas": "2058-46-0",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1991-10-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Oxytetracycline",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Oxythioquinox (Chinomethionat)",
   "cas": "2439-01-2",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "authoritative body",
     "listed": "1998-11-06",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": null,
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "p,p'-DDT",
   "cas": "50-29-3",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental, female, male",
     "mechanism": "authoritative body",
     "listed": "1998-05-15",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/DDT",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "p,p'-Oxybis(benzenesulfonyl hydrazide)  Delisted December 13, 2013 [Click here for the basis for delisting]",
   "cas": "80-51-3",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "Labor Code",
     "listed": "2009-08-07",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/p,p'-Oxybis(benzenesulfonyl_hydrazide)__Delisted_December_13,_2013_[Click_here_for_the_basis_for_delisting]",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Paclitaxel",
   "cas": "33069-62-4",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental, female, male",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1997-08-26",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Paclitaxel",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Paramethadione",
   "cas": "115-67-3",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1990-07-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Paramethadione",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Penicillamine",
   "cas": "52-67-5",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1991-01-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Penicillamine",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Pentobarbital sodium",
   "cas": "57-33-0",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1990-07-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Pentobarbital",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Pentostatin",
   "cas": "53910-25-1",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1996-09-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Pentostatin",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Perfluorooctane sulfonate (PFOS)",
   "cas": "1763-23-1",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "authoritative body",
     "listed": "2017-11-10",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Perfluorooctanesulfonic_acid",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "perfluorooctanoic acid",
   "cas": "335-67-1",
   "ec": "206-397-9",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "ATP05",
     "applies_from": "2015-01-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32013R0944",
     "index": "607-704-00-2"
    },
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "authoritative body",
     "listed": "2017-11-10",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "clp": "presumed",
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    },
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Perfluorooctanoic_acid",
   "level": "known",
   "source_codes": [
    "clp",
    "p65"
   ]
  },
  {
   "name": "Pertuzumab",
   "cas": "380610-27-5",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "2017-01-27",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Pertuzumab",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Phenacemide",
   "cas": "63-98-9",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1990-07-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Phenacemide",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Phenprocoumon",
   "cas": "435-97-2",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1992-10-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Phenprocoumon",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Phenylphosphine [Basis for listing changed effective June 6, 2014]",
   "cas": "638-21-1",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental male",
     "mechanism": "LC SQE",
     "listed": "2009-08-07",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Phenylphosphine",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Pimozide",
   "cas": "2062-78-4",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental, female",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1999-08-20",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Pimozide",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Pipobroman",
   "cas": "54-91-1",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1990-07-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Pipobroman",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Plicamycin",
   "cas": "18378-89-7",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1990-04-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Plicamycin",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Polybrominated biphenyls",
   "cas": "",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "authoritative body",
     "listed": "1994-10-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Polybrominated_biphenyl",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Polychlorinated biphenyls",
   "cas": "",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "State's Qualified Experts",
     "listed": "1991-01-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Polychlorinated_biphenyl",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Potassium dimethyldithiocarbamate",
   "cas": "128-03-0",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "authoritative body",
     "listed": "1999-03-30",
     "madl_ug_day": "720",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Sodium_dimethyldithiocarbamate",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Pravastatin sodium",
   "cas": "81131-70-6",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "2000-03-03",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Pravastatin",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Prednisolone sodium phosphate",
   "cas": "125-02-0",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1999-08-20",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Prednisolone_sodium_phosphate",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Procarbazine hydrochloride",
   "cas": "366-70-1",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1990-07-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Procarbazine",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Propargite",
   "cas": "2312-35-8",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "authoritative body",
     "listed": "1999-06-15",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Propargite",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Propazine",
   "cas": "139-40-2",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental, female",
     "mechanism": "authoritative body",
     "listed": "2016-07-15",
     "madl_ug_day": "100 (oral)",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": null,
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Propylthiouracil",
   "cas": "51-52-5",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1990-07-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Propylthiouracil",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Pyrimethamine",
   "cas": "58-14-0",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1999-01-29",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Pyrimethamine",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Quazepam",
   "cas": "36735-22-5",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1997-08-26",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Quazepam",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Resmethrin",
   "cas": "10453-86-8",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "authoritative body",
     "listed": "1998-11-06",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Resmethrin",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Retinol/retinyl esters, when in daily dosages in excess of 10,000 IU, or 3,000 retinol equivalents.  (NOTE:  Retinol/retinyl esters are required and essential for maintenance of normal reproductive function.  The recommended daily level during pregnancy is 8,000 IU.)",
   "cas": "",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "State's Qualified Experts",
     "listed": "1989-07-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": null,
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Ribavirin",
   "cas": "36791-04-5",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1990-04-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Ribavirin",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Rifampin",
   "cas": "13292-46-1",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental, female",
     "mechanism": "formally required to be labelled or identified",
     "listed": "2001-02-27",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Rifampicin",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Secobarbital sodium",
   "cas": "309-43-3",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1992-10-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Secobarbital",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Sermorelin acetate",
   "cas": "",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1999-08-20",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Sermorelin",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "silicic acid, lead nickel salt",
   "cas": "68130-19-8",
   "ec": "-",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1A",
     "statements": [
      "H360Df"
     ],
     "developmental_specific": true,
     "atp": "ATP02",
     "applies_from": "2012-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32011R0286",
     "index": "028-050-00-9"
    }
   ],
   "status": {
    "clp": "known"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": null,
   "level": "known",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "Simazine",
   "cas": "122-34-9",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental, female",
     "mechanism": "authoritative body",
     "listed": "2016-07-15",
     "madl_ug_day": "100 (oral)",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Simazine",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "slimes and sludges, copper electrolyte refining, decopperised",
   "cas": "94551-87-8",
   "ec": "305-433-1",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1A",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "ATP02",
     "applies_from": "2012-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32011R0286",
     "index": "028-015-00-8"
    }
   ],
   "status": {
    "clp": "known"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": null,
   "level": "known",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "Sodium dimethyldithiocarbamate",
   "cas": "128-04-1",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "authoritative body",
     "listed": "1999-03-30",
     "madl_ug_day": "23 (oral)\n58 (oral) as a 40% pesticidal formulation",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Sodium_dimethyldithiocarbamate",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Streptomycin sulfate",
   "cas": "3810-74-0",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1991-01-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Streptomycin",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Streptozocin (streptozotocin)",
   "cas": "18883-66-4",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental, female, male",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1999-08-20",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Streptozotocin",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Sulfur dioxidee",
   "cas": "7446-09-5",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "State's Qualified Experts",
     "listed": "2011-07-29",
     "madl_ug_day": "10000",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Sulfur_dioxide",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Sulindac",
   "cas": "38194-50-2",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental, female",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1999-01-29",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Sulindac",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Tamoxifen citrate",
   "cas": "54965-24-1",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1990-07-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Tamoxifen",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Temazepam",
   "cas": "846-50-4",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1990-04-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Temazepam",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Teniposide",
   "cas": "29767-20-2",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1996-09-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Teniposide",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Terbacil",
   "cas": "5902-51-2",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "authoritative body",
     "listed": "1999-05-18",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": null,
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "tert-Amyl methyl ether  Delisted December 13, 2013 [Click here for the basis for delisting]",
   "cas": "994-05-8",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "Labor Code",
     "listed": "2009-12-18",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Tert-Amyl_methyl_ether",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Testosterone cypionate",
   "cas": "58-20-8",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1991-10-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Testosterone_cypionate",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Testosterone enanthate",
   "cas": "315-37-7",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1990-04-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Testosterone_enanthate",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "tetracarbonylnickel; nickel tetracarbonyl",
   "cas": "13463-39-3",
   "ec": "236-669-2",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "CLP00",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "028-001-00-1"
    },
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "authoritative body",
     "listed": "1996-09-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "clp": "presumed",
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    },
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Nickel_tetracarbonyl",
   "level": "known",
   "source_codes": [
    "clp",
    "p65"
   ]
  },
  {
   "name": "Tetracycline (internal use)",
   "cas": "60-54-8",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1991-10-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Tetracycline",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Tetracycline hydrochloride (internal use)",
   "cas": "64-75-5",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1991-01-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Tetracycline",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Tetracyclines (internal use)",
   "cas": "",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1992-10-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Tetracycline_antibiotics",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Thalidomide",
   "cas": "50-35-1",
   "ec": "",
   "kind": "medicine",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "State's Qualified Experts",
     "listed": "1987-07-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    },
    {
     "label": "EMA: pregnancy prevention programme or contraindication for teratogenicity",
     "code": "ema",
     "note": "Thalidomide BMS (Celgene): authorised for multiple myeloma with a pregnancy prevention programme; the reference teratogen.",
     "url": "https://www.ema.europa.eu/en/medicines/human/EPAR/thalidomide-bms",
     "url_status": 200
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity",
    "ema": "known"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    },
    "EU / EEA": "Authorised (multiple myeloma) only within a pregnancy prevention programme; contraindicated in pregnancy and in women of childbearing potential without the programme.",
    "USA": "Authorised under the FDA THALOMID REMS programme."
   },
   "wiki": "https://en.wikipedia.org/wiki/Thalidomide",
   "level": "known",
   "source_codes": [
    "ema",
    "p65"
   ]
  },
  {
   "name": "Thioguanine",
   "cas": "154-42-7",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1990-07-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Tioguanine",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Tobacco smoke (primary)",
   "cas": "",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental, female, male",
     "mechanism": "State's Qualified Experts",
     "listed": "1988-04-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Tobacco_smoking",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Tobramycin sulfate",
   "cas": "49842-07-1",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1990-07-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Tobramycin",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "toluene",
   "cas": "108-88-3",
   "ec": "203-625-9",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361d"
     ],
     "developmental_specific": true,
     "atp": "CLP00",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "601-021-00-3"
    },
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "State's Qualified Experts",
     "listed": "1991-01-01",
     "madl_ug_day": "7000c",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "clp": "suspected",
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    },
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Toluene",
   "level": "known",
   "source_codes": [
    "clp",
    "p65"
   ]
  },
  {
   "name": "Topiramate",
   "cas": "97240-79-4",
   "ec": "",
   "kind": "medicine",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "2015-11-27",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    },
    {
     "label": "EMA: pregnancy prevention programme or contraindication for teratogenicity",
     "code": "ema",
     "note": "Antiepileptic and migraine medicine: EMA referral of 2023 imposed a pregnancy prevention programme.",
     "url": "https://www.ema.europa.eu/en/medicines/human/referrals/topiramate",
     "url_status": 200
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity",
    "ema": "known"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    },
    "EU / EEA": "Authorised with a pregnancy prevention programme; contraindicated in pregnancy for migraine prevention and in epilepsy unless no alternative."
   },
   "wiki": "https://en.wikipedia.org/wiki/Topiramate",
   "level": "known",
   "source_codes": [
    "ema",
    "p65"
   ]
  },
  {
   "name": "Triadimefon",
   "cas": "43121-43-3",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental, female, male",
     "mechanism": "authoritative body",
     "listed": "1999-03-30",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Triadimefon",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Triazolam",
   "cas": "28911-01-5",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1990-04-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Triazolam",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Tributyltin methacrylate",
   "cas": "2155-70-6",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "authoritative body",
     "listed": "1999-12-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": null,
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Trichloroethylene",
   "cas": "79-01-6",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental, male",
     "mechanism": "authoritative body",
     "listed": "2014-01-31",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Trichloroethylene",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Trientine hydrochloride",
   "cas": "38260-01-4",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "2001-02-27",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Triethylenetetramine",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Triforine",
   "cas": "26644-46-2",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "authoritative body",
     "listed": "1999-06-18",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": null,
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "trilead bis(orthophosphate)",
   "cas": "7446-27-7",
   "ec": "231-205-5",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1A",
     "statements": [
      "H360Df"
     ],
     "developmental_specific": true,
     "atp": "CLP00",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "082-006-00-3"
    }
   ],
   "status": {
    "clp": "known"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Lead(II)_phosphate",
   "level": "known",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "Trilostane",
   "cas": "13647-35-3",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1990-04-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Trilostane",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Trimethadione",
   "cas": "127-48-0",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1991-01-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Trimethadione",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Trimetrexate glucuronate",
   "cas": "82952-64-5",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1997-08-26",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Trimetrexate",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Uracil mustard",
   "cas": "66-75-1",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental, female, male",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1992-01-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Uramustine",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Urethane (Ethyl carbamate)",
   "cas": "51-79-6",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "authoritative body",
     "listed": "1994-10-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Ethyl_carbamate",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Urofollitropin",
   "cas": "97048-13-0",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1990-04-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Urofollitropin",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Valproate (Valproic acid)",
   "cas": "99-66-1",
   "ec": "",
   "kind": "medicine",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "State's Qualified Experts",
     "listed": "1987-07-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    },
    {
     "label": "EMA: pregnancy prevention programme or contraindication for teratogenicity",
     "code": "ema",
     "note": "Antiepileptic: EMA referral of 2018 imposed a pregnancy prevention programme and new contraindications.",
     "url": "https://www.ema.europa.eu/en/medicines/human/referrals/valproate-related-substances-0",
     "url_status": 200
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity",
    "ema": "known"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    },
    "EU / EEA": "Authorised with a pregnancy prevention programme; contraindicated in pregnancy for epilepsy unless no alternative, and for bipolar disorder.",
    "USA": "Authorised with a boxed warning on foetal risk."
   },
   "wiki": "https://en.wikipedia.org/wiki/Valproate",
   "level": "known",
   "source_codes": [
    "ema",
    "p65"
   ]
  },
  {
   "name": "Vinblastine sulfate",
   "cas": "143-67-9",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1990-07-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Vinblastine",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "vinclozolin (ISO); N-3,5-dichlorophenyl-5-methyl-5-vinyl-1,3-oxazolidine-2,4-dione",
   "cas": "50471-44-8",
   "ec": "256-599-6",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360FD"
     ],
     "developmental_specific": true,
     "atp": "CLP00",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "607-307-00-4"
    },
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "authoritative body",
     "listed": "1998-05-15",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "clp": "presumed",
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    },
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Vinclozolin",
   "level": "known",
   "source_codes": [
    "clp",
    "p65"
   ]
  },
  {
   "name": "Vincristine sulfate",
   "cas": "2068-78-2",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "formally required to be labelled or identified",
     "listed": "1990-07-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Vincristine",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Vismodegib",
   "cas": "879085-55-9",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental, female, male",
     "mechanism": "formally required to be labelled or identified",
     "listed": "2017-01-27",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Vismodegib",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Warfarin",
   "cas": "81-81-2",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "State's Qualified Experts",
     "listed": "1987-07-01",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Warfarin",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "warfarin (ISO); 4-hydroxy-3-(3-oxo-1-phenylbutyl)-2H-chromen-2-one [1]",
   "cas": "",
   "ec": "201-377-6 [1]",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1A",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "ATP09",
     "applies_from": "2018-03-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32016R1179",
     "index": "607-056-00-0"
    }
   ],
   "status": {
    "clp": "known"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Warfarin",
   "level": "known",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "Zileuton",
   "cas": "111406-87-2",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "cancer, developmental, female",
     "mechanism": "formally required to be labelled or identified",
     "listed": "2000-12-22",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Zileuton",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "Δ9-Tetrahydrocannabinol (Δ9-THC)",
   "cas": "",
   "ec": "",
   "kind": "chemical",
   "sources": [
    {
     "label": "California Proposition 65 (developmental toxicant)",
     "code": "p65",
     "toxicity": "developmental",
     "mechanism": "State's Qualified Experts",
     "listed": "2020-01-03",
     "madl_ug_day": "",
     "url": "https://oehha.ca.gov/proposition-65/proposition-65-list"
    }
   ],
   "status": {
    "p65": "known to the State of California to cause developmental toxicity"
   },
   "jurisdictions": {
    "California (USA)": {
     "warning": "A clear and reasonable warning is required before knowingly exposing anyone in California (Health and Safety Code 25249.6); listing does not ban the substance.",
     "enforcement": "Attorney General, district attorneys and private enforcers; civil penalties up to USD 2,500 per violation per day."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Tetrahydrocannabinol",
   "level": "known",
   "source_codes": [
    "p65"
   ]
  },
  {
   "name": "1,2,4-triazole",
   "cas": "288-88-0",
   "ec": "206-022-9",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360FD"
     ],
     "developmental_specific": true,
     "atp": "ATP17",
     "applies_from": "2022-12-17",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32021R0849",
     "index": "613-111-00-X"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/1,2,4-Triazole",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "1,2-benzenedicarboxylic acid, dihexyl ester, branched and linear",
   "cas": "68515-50-4",
   "ec": "271-093-5",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360FD"
     ],
     "developmental_specific": true,
     "atp": "ATP07",
     "applies_from": "2017-01-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32015R1221",
     "index": "607-710-00-5"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": null,
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "1,2-benzenedicarboxylic acid, dipentylester, branched and linear [1]",
   "cas": "",
   "ec": "284-032-2 [1]",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360FD"
     ],
     "developmental_specific": true,
     "atp": "CLP00",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "607-426-00-1"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/1,2-benzenedicarboxylic_acid,_dipentylester,_branched_and_linear_[1]",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "1,2-benzenedicarboxylic acid; di-C6-8-branched alkylesters, C7-rich",
   "cas": "71888-89-6",
   "ec": "276-158-1",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "ATP01",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32009R0790",
     "index": "607-483-00-2"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Phthalic_acid",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "1,2-benzenedicarboxylic acid; di-C7-11-branched and linear alkylesters",
   "cas": "68515-42-4",
   "ec": "271-084-6",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360Df"
     ],
     "developmental_specific": true,
     "atp": "CLP00",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "607-480-00-6"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Phthalic_acid",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "1,2-bis(2-methoxyethoxy)ethane; TEGDME; triethylene glycol dimethyl ether; triglyme",
   "cas": "112-49-2",
   "ec": "203-977-3",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360Df"
     ],
     "developmental_specific": true,
     "atp": "CLP00",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "603-176-00-2"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Triethylene_glycol_dimethyl_ether",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "1,2-dimethoxyethane; ethylene glycol dimethyl ether; EGDME",
   "cas": "110-71-4",
   "ec": "203-794-9",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360FD"
     ],
     "developmental_specific": true,
     "atp": "CLP00",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "603-031-00-3"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Dimethoxyethane",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "1,4-Benzenediamine, N,N-mixed Ph and tolyl derivs.",
   "cas": "68953-84-4",
   "ec": "273-227-8",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360FD"
     ],
     "developmental_specific": true,
     "atp": "ATP21",
     "applies_from": "2025-09-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32024R0197",
     "index": "612-298-00-5"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": null,
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "1-vinylimidazole",
   "cas": "1072-63-5",
   "ec": "214-012-0",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "ATP13",
     "applies_from": "2020-05-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32018R1480",
     "index": "613-328-00-X"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/1-Vinylimidazole",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "2,4,6-tri-tert-butylphenol",
   "cas": "732-26-3",
   "ec": "211-989-5",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "ATP18",
     "applies_from": "2023-11-23",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32022R0692",
     "index": "604-097-00-6"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/2,4,6-Tri-tert-butylphenol",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "2-(2-aminoethylamino)ethanol; (AEEA)",
   "cas": "111-41-1",
   "ec": "203-867-5",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360Df"
     ],
     "developmental_specific": true,
     "atp": "ATP01corr",
     "applies_from": "2013-08-13",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32013R0758",
     "index": "603-194-00-0"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Aminoethylethanolamine",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "2-(2-methoxyethoxy)ethanol; diethylene glycol monomethyl ether",
   "cas": "111-77-3",
   "ec": "203-906-6",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "ATP18",
     "applies_from": "2023-11-23",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32022R0692",
     "index": "603-107-00-6"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/2-(2-Methoxyethoxy)ethanol",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "2-(4-tert-butylbenzyl)propionaldehyde",
   "cas": "80-54-6",
   "ec": "201-289-8",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360Fd"
     ],
     "developmental_specific": true,
     "atp": "ATP15",
     "applies_from": "2022-03-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32020R1182",
     "index": "605-041-00-3"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Lilial",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "2-(dimethylamino)-2-[(4-methylphenyl)methyl]-1-[4-(morpholin-4-yl)phenyl]butan-1-one",
   "cas": "119344-86-4",
   "ec": "438-340-0",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360Df"
     ],
     "developmental_specific": true,
     "atp": "ATP22",
     "applies_from": "2026-05-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32024R2564",
     "index": "606-158-00-2"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/2-(dimethylamino)-2-[(4-methylphenyl)methyl]-1-[4-(morpholin-4-yl)phenyl]butan-1-one",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "2-[2-hydroxy-3-(2-chlorophenyl)carbamoyl-1-naphthylazo]-7-[2-hydroxy-3-(3-methylphenyl)carbamoyl-1-naphthylazo]fluoren-9-one",
   "cas": "151798-26-4",
   "ec": "420-580-2",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "CLP00",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "611-131-00-3"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/2-[2-hydroxy-3-(2-chlorophenyl)carbamoyl-1-naphthylazo]-7-[2-hydroxy-3-(3-methylphenyl)carbamoyl-1-naphthylazo]fluoren-9-one",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "2-benzyl-2-dimethylamino-4'-morpholinobutyrophenone",
   "cas": "119313-12-1",
   "ec": "404-360-3",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "ATP14",
     "applies_from": "2021-09-09",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32020R0217",
     "index": "606-047-00-9"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": null,
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "2-bromo-3,3,3-trifluoroprop-1-ene",
   "cas": "1514-82-5",
   "ec": "-",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360FD"
     ],
     "developmental_specific": true,
     "atp": "ATP23",
     "applies_from": "2027-02-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32025R1222",
     "index": "602-112-00-0"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": null,
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "2-ethylhexanoic acid and its salts, with the exception of those specified elsewhere in this Annex",
   "cas": "",
   "ec": "-",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "ATP20",
     "applies_from": "2025-02-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32023R1435",
     "index": "607-230-00-6"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": null,
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "2-ethylhexanoic acid, monoester with propane-1,2-diol",
   "cas": "85114-00-7",
   "ec": "285-503-5",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "ATP23",
     "applies_from": "2027-02-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32025R1222",
     "index": "607-776-00-5"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": null,
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "2-ethylhexyl 10-ethyl-4,4-dioctyl-7-oxo-8-oxa-3,5-dithia-4-stannatetradecanoate; [DOTE]",
   "cas": "15571-58-1",
   "ec": "239-622-4",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "ATP15",
     "applies_from": "2022-03-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32020R1182",
     "index": "050-027-00-7"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": null,
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "2-ethylhexyl[[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methyl]thio]acetate",
   "cas": "80387-97-9",
   "ec": "279-452-8",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "CLP00",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "607-203-00-9"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/2-ethylhexyl[[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methyl]thio]acetate",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "2-methoxyethyl acrylate",
   "cas": "3121-61-7",
   "ec": "221-499-3",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360FD"
     ],
     "developmental_specific": true,
     "atp": "ATP15",
     "applies_from": "2022-03-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32020R1182",
     "index": "607-744-00-0"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": null,
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "2-methoxypropanol",
   "cas": "1589-47-5",
   "ec": "216-455-5",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "CLP00",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "603-106-00-0"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": null,
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "2-methoxypropyl acetate",
   "cas": "70657-70-4",
   "ec": "274-724-2",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "CLP00",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "607-251-00-0"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": null,
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "2-methyl-1-(4-methylthiophenyl)-2-morpholinopropan-1-one",
   "cas": "71868-10-5",
   "ec": "400-600-6",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360FD"
     ],
     "developmental_specific": true,
     "atp": "ATP10",
     "applies_from": "2018-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32017R0776",
     "index": "606-041-00-6"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": null,
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "2-methylimidazole",
   "cas": "693-98-1",
   "ec": "211-765-7",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360Df"
     ],
     "developmental_specific": true,
     "atp": "ATP14",
     "applies_from": "2021-09-09",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32020R0217",
     "index": "613-330-00-0"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/2-Methylimidazole",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "3-methylpyrazole",
   "cas": "1453-58-3",
   "ec": "215-925-7",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "ATP17",
     "applies_from": "2022-12-17",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32021R0849",
     "index": "613-339-00-X"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": null,
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "4-methylimidazole",
   "cas": "822-36-6",
   "ec": "212-497-3",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360Fd"
     ],
     "developmental_specific": true,
     "atp": "ATP21",
     "applies_from": "2025-09-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32024R0197",
     "index": "613-349-00-4"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/4-Methylimidazole",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "6-[(C10-C13)-alkyl-(branched, unsaturated)-2,5-dioxopyrrolidin-1-yl]hexanoic acid",
   "cas": "2156592-54-8",
   "ec": "-",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360FD"
     ],
     "developmental_specific": true,
     "atp": "ATP18",
     "applies_from": "2023-11-23",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32022R0692",
     "index": "607-764-00-X"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/6-[(C10-C13)-alkyl-(branched,_unsaturated)-2,5-dioxopyrrolidin-1-yl]hexanoic_acid",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "6-[C12-18-alkyl-(branched, unsaturated)-2,5-dioxopyrrolidin-1-yl]hexanoic acid",
   "cas": "",
   "ec": "-",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360FD"
     ],
     "developmental_specific": true,
     "atp": "ATP18",
     "applies_from": "2023-11-23",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32022R0692",
     "index": "607-765-00-5"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/6-[C12-18-alkyl-(branched,_unsaturated)-2,5-dioxopyrrolidin-1-yl]hexanoic_acid",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "6-[C12-18-alkyl-(branched, unsaturated)-2,5-dioxopyrrolidin-1-yl]hexanoic acid, sodium and tris(2-hydroxyethyl)ammonium salts",
   "cas": "",
   "ec": "-",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360FD"
     ],
     "developmental_specific": true,
     "atp": "ATP18",
     "applies_from": "2023-11-23",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32022R0692",
     "index": "607-763-00-4"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/6-[C12-18-alkyl-(branched,_unsaturated)-2,5-dioxopyrrolidin-1-yl]hexanoic_acid,_sodium_and_tris(2-hydroxyethyl)ammonium_salts",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "7-methoxy-6-(3-morpholin-4-yl-propoxy)-3H-quinazolin-4-one; [containing ≥ 0,5 % formamide (EC No 200-842-0)]",
   "cas": "199327-61-2",
   "ec": "429-400-7",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "ATP01",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32009R0790",
     "index": "612-253-01-7"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": null,
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "9-octadecenoic acid (Z)-, sulfonated, potassium salts [1]",
   "cas": "",
   "ec": "271-843-1 [1]",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "ATP23",
     "applies_from": "2027-02-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32025R1222",
     "index": "607-779-00-1"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": null,
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "Ambrisentan (endothelin receptor antagonist)",
   "cas": "177036-94-1",
   "ec": "",
   "kind": "medicine",
   "sources": [
    {
     "label": "EMA: pregnancy prevention programme or contraindication for teratogenicity",
     "code": "ema",
     "note": "Pulmonary arterial hypertension medicine (Volibris); teratogenic in animals.",
     "url": "https://www.ema.europa.eu/en/medicines/human/EPAR/volibris",
     "url_status": 200
    }
   ],
   "status": {
    "ema": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": "Authorised; contraindicated in pregnancy."
   },
   "wiki": "https://en.wikipedia.org/wiki/Ambrisentan",
   "level": "presumed",
   "source_codes": [
    "ema"
   ]
  },
  {
   "name": "ammonium bromide",
   "cas": "12124-97-9",
   "ec": "235-183-8",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360FD"
     ],
     "developmental_specific": true,
     "atp": "ATP18",
     "applies_from": "2023-11-23",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32022R0692",
     "index": "035-005-00-7"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Ammonium_bromide",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "ammonium dichromate",
   "cas": "7789-09-5",
   "ec": "232-143-1",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360FD"
     ],
     "developmental_specific": true,
     "atp": "CLP00",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "024-003-00-1"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Ammonium_dichromate",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "ammoniumpentadeca- fluorooctanoate",
   "cas": "3825-26-1",
   "ec": "223-320-4",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "ATP05",
     "applies_from": "2015-01-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32013R0944",
     "index": "607-703-00-7"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": null,
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "azafenidin (ISO); 2-(2,4-dichloro-5-prop-2-ynyloxyphenyl)-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyridin-3(2H)-one",
   "cas": "68049-83-2",
   "ec": "-",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360Df"
     ],
     "developmental_specific": true,
     "atp": "CLP00",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "611-140-00-2"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": null,
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "barium diboron tetraoxide",
   "cas": "13701-59-2",
   "ec": "237-222-4",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360FD"
     ],
     "developmental_specific": true,
     "atp": "ATP18",
     "applies_from": "2023-11-23",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32022R0692",
     "index": "056-005-00-3"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Barium_borate",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "benzo[a]pyrene; benzo[def]chrysene",
   "cas": "50-32-8",
   "ec": "200-028-5",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360FD"
     ],
     "developmental_specific": true,
     "atp": "CLP00",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "601-032-00-3"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Benzo(a)pyrene",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "binapacryl (ISO); 2-sec-butyl-4,6-dinitrophenyl-3-methylcrotonate",
   "cas": "485-31-4",
   "ec": "207-612-9",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "CLP00",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "609-024-00-1"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Binapacryl",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "bis(2-(2-methoxyethoxy)ethyl)ether; tetraglyme",
   "cas": "143-24-8",
   "ec": "205-594-7",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360FD"
     ],
     "developmental_specific": true,
     "atp": "ATP15",
     "applies_from": "2022-03-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32020R1182",
     "index": "603-238-00-9"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Tetraethylene_glycol_dimethyl_ether",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "bis(2-methoxyethyl) ether",
   "cas": "111-96-6",
   "ec": "203-924-4",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360FD"
     ],
     "developmental_specific": true,
     "atp": "CLP00",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "603-139-00-0"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Diglyme",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "bis(2-methoxyethyl) phthalate",
   "cas": "117-82-8",
   "ec": "204-212-6",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360Df"
     ],
     "developmental_specific": true,
     "atp": "CLP00",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "607-228-00-5"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Bis(2-methoxyethyl)_phthalate",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "bis(α,α-dimethylbenzyl) peroxide",
   "cas": "80-43-3",
   "ec": "201-279-3",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "ATP15",
     "applies_from": "2022-03-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32020R1182",
     "index": "617-006-00-X"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Dicumyl_peroxide",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "boric acid [1]",
   "cas": "",
   "ec": "233-139-2 [1]",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360FD"
     ],
     "developmental_specific": true,
     "atp": "ATP20",
     "applies_from": "2025-02-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32023R1435",
     "index": "005-007-00-2"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/boric_acid_[1]",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "Bosentan (endothelin receptor antagonist)",
   "cas": "147536-97-8",
   "ec": "",
   "kind": "medicine",
   "sources": [
    {
     "label": "EMA: pregnancy prevention programme or contraindication for teratogenicity",
     "code": "ema",
     "note": "Pulmonary arterial hypertension medicine (Tracleer); teratogenic in animals; monthly pregnancy testing.",
     "url": "https://www.ema.europa.eu/en/medicines/human/EPAR/tracleer",
     "url_status": 200
    }
   ],
   "status": {
    "ema": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": "Authorised; contraindicated in pregnancy and in women of childbearing potential not using reliable contraception."
   },
   "wiki": "https://en.wikipedia.org/wiki/Bosentan",
   "level": "presumed",
   "source_codes": [
    "ema"
   ]
  },
  {
   "name": "bromadiolone (ISO); 3-[3-(4′-bromobiphenyl-4-yl)-3-hydroxy-1-phenylpropyl]-4-hydroxy-2H-chromen-2-one",
   "cas": "28772-56-7",
   "ec": "249-205-9",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "ATP09",
     "applies_from": "2018-03-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32016R1179",
     "index": "607-716-00-8"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Bromadiolone",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "cadmium chloride",
   "cas": "10108-64-2",
   "ec": "233-296-7",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360FD"
     ],
     "developmental_specific": true,
     "atp": "CLP00",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "048-008-00-3"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Cadmium_chloride",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "cadmium fluoride",
   "cas": "7790-79-6",
   "ec": "232-222-0",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360FD"
     ],
     "developmental_specific": true,
     "atp": "CLP00",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "048-006-00-2"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Cadmium_fluoride",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "cadmium sulphate",
   "cas": "10124-36-4",
   "ec": "233-331-6",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360FD"
     ],
     "developmental_specific": true,
     "atp": "CLP00",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "048-009-00-9"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Cadmium_sulfate",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "carbendazim (ISO); methyl benzimidazol-2-ylcarbamate",
   "cas": "10605-21-7",
   "ec": "234-232-0",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360FD"
     ],
     "developmental_specific": true,
     "atp": "ATP17",
     "applies_from": "2022-12-17",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32021R0849",
     "index": "613-048-00-8"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Carbendazim",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "carbetamide (ISO); (R)-1-(ethylcarbamoyl)ethyl carbanilate; (2R)-1-(ethylamino)-1-oxopropan-2-yl phenylcarbamate",
   "cas": "16118-49-3",
   "ec": "240-286-6",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "ATP10",
     "applies_from": "2018-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32017R0776",
     "index": "616-223-00-7"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": null,
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "chloro-N,N-dimethylformiminium chloride",
   "cas": "3724-43-4",
   "ec": "425-970-6",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "ATP01",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32009R0790",
     "index": "612-250-00-3"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Vilsmeier_reagent",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "chlorophacinone (ISO); 2-[(4-chlorophenyl)(phenyl)acetyl]-1H-indene-1,3(2H)-dione",
   "cas": "3691-35-8",
   "ec": "223-003-0",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "ATP09",
     "applies_from": "2018-03-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32016R1179",
     "index": "606-014-00-9"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Chlorophacinone",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "coumatetralyl (ISO); 4-hydroxy-3-(1,2,3,4-tetrahydro-1-naphthyl)coumarin",
   "cas": "5836-29-3",
   "ec": "227-424-0",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "ATP09",
     "applies_from": "2018-03-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32016R1179",
     "index": "607-059-00-7"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Coumatetralyl",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "cyproconazole (ISO); (2RS,3RS;2RS,3SR)-2-(4-chlorophenyl)-3-cyclopropyl-1-(1H-1,2,4-triazol-1-yl)butan-2-ol",
   "cas": "94361-06-5",
   "ec": "-",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "ATP10",
     "applies_from": "2018-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32017R0776",
     "index": "650-032-00-X"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Cyproconazole",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "diboron trioxide",
   "cas": "1303-86-2",
   "ec": "215-125-8",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360FD"
     ],
     "developmental_specific": true,
     "atp": "ATP20",
     "applies_from": "2025-02-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32023R1435",
     "index": "005-008-00-8"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Boron_trioxide",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "dibutylbis(pentane-2,4-dionato-O,O)tin",
   "cas": "22673-19-4",
   "ec": "245-152-0",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360FD"
     ],
     "developmental_specific": true,
     "atp": "ATP14",
     "applies_from": "2021-09-09",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32020R0217",
     "index": "650-056-00-0"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": null,
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "dibutyltin bis(2-ethylhexanoate)",
   "cas": "2781-10-4",
   "ec": "220-481-2",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360FD"
     ],
     "developmental_specific": true,
     "atp": "ATP18",
     "applies_from": "2023-11-23",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32022R0692",
     "index": "050-032-00-4"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": null,
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "dibutyltin di(acetate)",
   "cas": "1067-33-0",
   "ec": "213-928-8",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360FD"
     ],
     "developmental_specific": true,
     "atp": "ATP18",
     "applies_from": "2023-11-23",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32022R0692",
     "index": "050-033-00-X"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": null,
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "dibutyltin dichloride; (DBTC)",
   "cas": "683-18-1",
   "ec": "211-670-0",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360FD"
     ],
     "developmental_specific": true,
     "atp": "ATP01",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32009R0790",
     "index": "050-022-00-X"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": null,
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "dibutyltin dilaurate; dibutyl[bis(dodecanoyloxy)]stannane",
   "cas": "77-58-7",
   "ec": "201-039-8",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360FD"
     ],
     "developmental_specific": true,
     "atp": "ATP10",
     "applies_from": "2018-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32017R0776",
     "index": "050-030-00-3"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Dibutyltin_dilaurate",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "dibutyltin hydrogen borate",
   "cas": "75113-37-0",
   "ec": "401-040-5",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360FD"
     ],
     "developmental_specific": true,
     "atp": "ATP01corr",
     "applies_from": "2013-08-13",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32013R0758",
     "index": "005-006-00-7"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": null,
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "dibutyltin maleate",
   "cas": "78-04-6",
   "ec": "201-077-5",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360FD"
     ],
     "developmental_specific": true,
     "atp": "ATP21",
     "applies_from": "2025-09-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32024R0197",
     "index": "050-034-00-5"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": null,
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "dibutyltin oxide",
   "cas": "818-08-6",
   "ec": "212-449-1",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360FD"
     ],
     "developmental_specific": true,
     "atp": "ATP21",
     "applies_from": "2025-09-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32024R0197",
     "index": "050-035-00-0"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Dibutyltin_oxide",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "dichlorodioctylstannane",
   "cas": "3542-36-7",
   "ec": "222-583-2",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "ATP15",
     "applies_from": "2022-03-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32020R1182",
     "index": "050-021-00-4"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": null,
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "dicyclohexyl phthalate",
   "cas": "84-61-7",
   "ec": "201-545-9",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "ATP09",
     "applies_from": "2018-03-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32016R1179",
     "index": "607-719-00-4"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": null,
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "difenacoum (ISO); 3-(3-biphenyl-4-yl-1,2,3,4-tetrahydro-1-naphthyl)-4-hydroxycoumarin",
   "cas": "56073-07-5",
   "ec": "259-978-4",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "ATP09",
     "applies_from": "2018-03-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32016R1179",
     "index": "607-157-00-X"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Difenacoum",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "difethialone (ISO); 3-[3-(4′-bromobiphenyl-4-yl)-1,2,3,4-tetrahydronaphthalen-1-yl]-4-hydroxy-2H-1-benzothiopyran-2-one",
   "cas": "104653-34-1",
   "ec": "-",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "ATP09",
     "applies_from": "2018-03-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32016R1179",
     "index": "607-717-00-3"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Difethialone",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "dihexyl phthalate",
   "cas": "84-75-3",
   "ec": "201-559-5",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360FD"
     ],
     "developmental_specific": true,
     "atp": "ATP05",
     "applies_from": "2015-01-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32013R0944",
     "index": "607-702-00-1"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": null,
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "diisobutyl phthalate",
   "cas": "84-69-5",
   "ec": "201-553-2",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360Df"
     ],
     "developmental_specific": true,
     "atp": "ATP09",
     "applies_from": "2018-03-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32016R1179",
     "index": "607-623-00-2"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Diisobutyl_phthalate",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "diisohexyl phthalate",
   "cas": "71850-09-4",
   "ec": "276-090-2",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360FD"
     ],
     "developmental_specific": true,
     "atp": "ATP14",
     "applies_from": "2021-09-09",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32020R0217",
     "index": "607-737-00-2"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": null,
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "diisooctyl phthalate",
   "cas": "27554-26-3",
   "ec": "248-523-5",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360FD"
     ],
     "developmental_specific": true,
     "atp": "ATP15",
     "applies_from": "2022-03-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32020R1182",
     "index": "607-740-00-9"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": null,
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "dimethyl propylphosphonate",
   "cas": "18755-43-6",
   "ec": "242-555-3",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360Df"
     ],
     "developmental_specific": true,
     "atp": "ATP21",
     "applies_from": "2025-09-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32024R0197",
     "index": "015-208-00-7"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": null,
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "dinoterb (ISO); 2-tert-butyl-4,6-dinitrophenol",
   "cas": "1420-07-1",
   "ec": "215-813-8",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "CLP00",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "609-030-00-4"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Dinoterb",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "dioctyltin dilaurate [1]",
   "cas": "",
   "ec": "222-883-3 [1]",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "ATP15",
     "applies_from": "2022-03-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32020R1182",
     "index": "050-031-00-9"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/dioctyltin_dilaurate_[1]",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide",
   "cas": "75980-60-8",
   "ec": "278-355-8",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360Fd"
     ],
     "developmental_specific": true,
     "atp": "ATP21",
     "applies_from": "2025-09-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32024R0197",
     "index": "015-203-00-X"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": null,
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "diphenylether; octabromo derivate",
   "cas": "32536-52-0",
   "ec": "251-087-9",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360Df"
     ],
     "developmental_specific": true,
     "atp": "CLP00",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "602-094-00-4"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Octabromodiphenyl_ether",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "disodium octaborate anhydrous [1]",
   "cas": "",
   "ec": "234-541-0 [1]",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360FD"
     ],
     "developmental_specific": true,
     "atp": "ATP09",
     "applies_from": "2018-03-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32016R1179",
     "index": "005-020-00-3"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/disodium_octaborate_anhydrous_[1]",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "epoxiconazole (ISO); (2RS,3SR)-3-(2-chlorophenyl)-2-(4-fluorophenyl)-[( 1H-1,2,4-triazol-1-yl)methyl]oxirane",
   "cas": "133855-98-8",
   "ec": "406-850-2",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360Df"
     ],
     "developmental_specific": true,
     "atp": "ATP05",
     "applies_from": "2015-01-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32013R0944",
     "index": "613-175-00-9"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Epoxiconazole",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "etacelasil (ISO); 6-(2-chloroethyl)-6-(2-methoxyethoxy)-2,5,7,10-tetraoxa-6-silaundecane",
   "cas": "37894-46-5",
   "ec": "253-704-7",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "CLP00",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "014-014-00-X"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": null,
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "ethanol, 2,2-iminobis-, N-(C13-15-branched and linear alkyl) derivs.",
   "cas": "97925-95-6",
   "ec": "308-208-6",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "ATP14",
     "applies_from": "2021-09-09",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32020R0217",
     "index": "603-236-00-8"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": null,
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "flocoumafen (ISO); reaction mass of: cis-4-hydroxy-3-(1,2,3,4-tetrahydro-3-(4-(4-trifluoromethylbenzyloxy)phenyl)-1-naphthyl)coumarin and trans-4-hydroxy-3-(1,2,3,4-tetrahydro-3-(4-(4-trifluoromethylbenzyloxy)phenyl)-1-naphthyl)coumarin",
   "cas": "90035-08-8",
   "ec": "421-960-0",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "ATP09",
     "applies_from": "2018-03-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32016R1179",
     "index": "607-375-00-5"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Flocoumafen",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "flurochloridone (ISO); 3-chloro-4-(chloromethyl)-1-[3-(trifluoromethyl)phenyl]pyrrolidin-2-one",
   "cas": "61213-25-0",
   "ec": "262-661-3",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360FD"
     ],
     "developmental_specific": true,
     "atp": "ATP15",
     "applies_from": "2022-03-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32020R1182",
     "index": "613-334-00-2"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": null,
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "flusilazole (ISO); bis(4-fluorophenyl)(methyl)(1H-1,2,4-triazol-1-ylmethyl)silane",
   "cas": "85509-19-9",
   "ec": "-",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "CLP00",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "014-017-00-6"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Flusilazole",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "formamide",
   "cas": "75-12-7",
   "ec": "200-842-0",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "CLP00",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "616-052-00-8"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Formamide",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "glufosinate ammonium (ISO); ammonium 2-amino-4-(hydroxymethylphosphinyl)butyrate",
   "cas": "77182-82-2",
   "ec": "278-636-5",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360Fd"
     ],
     "developmental_specific": true,
     "atp": "ATP01",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32009R0790",
     "index": "015-155-00-X"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Glufosinate",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "halosulfuron-methyl (ISO); methyl 3-chloro-5-{[(4,6-dimethoxypyrimidin-2-yl)carbamoyl]sulfamoyl}-1-methyl-1H-pyrazole-4-carboxylate",
   "cas": "100784-20-1",
   "ec": "-",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "ATP14",
     "applies_from": "2021-09-09",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32020R0217",
     "index": "613-329-00-5"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Halosulfuron-methyl",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "imidazole",
   "cas": "288-32-4",
   "ec": "206-019-2",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "ATP07",
     "applies_from": "2017-01-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32015R1221",
     "index": "613-319-00-0"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Imidazole",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "ipconazole (ISO); (1RS,2SR,5RS;1RS,2SR,5SR)-2-(4-chlorobenzyl)-5-isopropyl-1-(1H-1,2,4-triazol-1-ylmethyl)cyclopentanol [1]",
   "cas": "",
   "ec": "- [1]",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "ATP15",
     "applies_from": "2022-03-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32020R1182",
     "index": "603-237-00-3"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": null,
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "Lenalidomide",
   "cas": "191732-72-6",
   "ec": "",
   "kind": "medicine",
   "sources": [
    {
     "label": "EMA: pregnancy prevention programme or contraindication for teratogenicity",
     "code": "ema",
     "note": "Thalidomide analogue (Revlimid): pregnancy prevention programme.",
     "url": "https://www.ema.europa.eu/en/medicines/human/EPAR/revlimid",
     "url_status": 200
    }
   ],
   "status": {
    "ema": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": "Authorised within a pregnancy prevention programme; contraindicated in pregnancy.",
    "USA": "Authorised under an FDA REMS programme."
   },
   "wiki": "https://en.wikipedia.org/wiki/Lenalidomide",
   "level": "presumed",
   "source_codes": [
    "ema"
   ]
  },
  {
   "name": "Macitentan (endothelin receptor antagonist)",
   "cas": "441798-33-0",
   "ec": "",
   "kind": "medicine",
   "sources": [
    {
     "label": "EMA: pregnancy prevention programme or contraindication for teratogenicity",
     "code": "ema",
     "note": "Pulmonary arterial hypertension medicine (Opsumit); teratogenic in animals.",
     "url": "https://www.ema.europa.eu/en/medicines/human/EPAR/opsumit",
     "url_status": 200
    }
   ],
   "status": {
    "ema": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": "Authorised; contraindicated in pregnancy."
   },
   "wiki": "https://en.wikipedia.org/wiki/Macitentan",
   "level": "presumed",
   "source_codes": [
    "ema"
   ]
  },
  {
   "name": "mancozeb (ISO); manganese ethylenebis(dithiocarbamate) (polymeric) complex with zinc salt",
   "cas": "8018-01-7",
   "ec": "-",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "ATP17",
     "applies_from": "2022-12-17",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32021R0849",
     "index": "006-076-00-1"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Mancozeb",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "mercury",
   "cas": "7439-97-6",
   "ec": "231-106-7",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "ATP01",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32009R0790",
     "index": "080-001-00-0"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Mercury_(element)",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "methoxyacetic acid",
   "cas": "625-45-6",
   "ec": "210-894-6",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360FD"
     ],
     "developmental_specific": true,
     "atp": "CLP00",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "607-312-00-1"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Methoxyacetic_acid",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "methyl-ONN-azoxymethyl acetate; methyl azoxy methyl acetate",
   "cas": "592-62-1",
   "ec": "209-765-7",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "CLP00",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "611-004-00-2"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Methylazoxymethanol_acetate",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "N,N-(dimethylamino)thioacetamide hydrochloride",
   "cas": "27366-72-9",
   "ec": "435-470-1",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "ATP01",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32009R0790",
     "index": "616-180-00-4"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": null,
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "N,N-dimethylformamide; dimethyl formamide",
   "cas": "68-12-2",
   "ec": "200-679-5",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "CLP00",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "616-001-00-X"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Dimethylformamide",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "N-(2-nitrophenyl)phosphoric triamide",
   "cas": "874819-71-3",
   "ec": "477-690-9",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360Fd"
     ],
     "developmental_specific": true,
     "atp": "ATP18",
     "applies_from": "2023-11-23",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32022R0692",
     "index": "616-238-00-9"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": null,
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "N-[6,9-dihydro-9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]-6-oxo-1H-purin-2-yl]acetamide",
   "cas": "84245-12-5",
   "ec": "424-550-1",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360FD"
     ],
     "developmental_specific": true,
     "atp": "ATP01",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32009R0790",
     "index": "616-148-00-X"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/N-[6,9-dihydro-9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]-6-oxo-1H-purin-2-yl]acetamide",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "N-carboxymethyliminobis(ethylenenitrilo)tetra(acetic acid)",
   "cas": "67-43-6",
   "ec": "200-652-8",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "ATP18",
     "applies_from": "2023-11-23",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32022R0692",
     "index": "607-735-00-1"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Pentetic_acid",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "N-ethyl-2-pyrrolidone; 1-ethylpyrrolidin-2-one",
   "cas": "2687-91-4",
   "ec": "220-250-6",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "ATP05",
     "applies_from": "2015-01-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32013R0944",
     "index": "616-208-00-5"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": null,
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "N-methylacetamide",
   "cas": "79-16-3",
   "ec": "201-182-6",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "CLP00",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "616-053-00-3"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/N-Methylacetamide",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "N-methylformamide",
   "cas": "123-39-7",
   "ec": "204-624-6",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "CLP00",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "616-056-00-X"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/N-Methylformamide",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "nickel bis(4-cyclohexylbutyrate)",
   "cas": "3906-55-6",
   "ec": "223-463-2",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "ATP01",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32009R0790",
     "index": "028-025-00-2"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": null,
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "nickel bis(sulfamidate); nickel sulfamate",
   "cas": "13770-89-3",
   "ec": "237-396-1",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "ATP14",
     "applies_from": "2021-09-09",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32020R0217",
     "index": "028-018-00-4"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": null,
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "nickel bis(tetrafluoroborate)",
   "cas": "14708-14-6",
   "ec": "238-753-4",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "ATP02",
     "applies_from": "2012-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32011R0286",
     "index": "028-019-00-X"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": null,
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "nickel carbonate; basic nickel carbonate; carbonic acid, nickel (2+) salt [1]",
   "cas": "",
   "ec": "222-068-2 [1]",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "ATP01",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32009R0790",
     "index": "028-010-00-0"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Nickel(II)_carbonate",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "nickel di(acetate) [1]",
   "cas": "",
   "ec": "206-761-7 [1]",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "ATP01corr",
     "applies_from": "2013-08-13",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32013R0758",
     "index": "028-022-00-6"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/nickel_di(acetate)_[1]",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "nickel dibenzoate",
   "cas": "553-71-9",
   "ec": "209-046-8",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "ATP02",
     "applies_from": "2012-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32011R0286",
     "index": "028-024-00-7"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": null,
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "nickel dichlorate [1]",
   "cas": "",
   "ec": "267-897-0 [1]",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "ATP02",
     "applies_from": "2012-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32011R0286",
     "index": "028-053-00-5"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/nickel_dichlorate_[1]",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "nickel dichloride",
   "cas": "7718-54-9",
   "ec": "231-743-0",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "ATP01corr",
     "applies_from": "2013-08-13",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32013R0758",
     "index": "028-011-00-6"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Nickel(II)_chloride",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "nickel dichromate",
   "cas": "15586-38-6",
   "ec": "239-646-5",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "ATP02",
     "applies_from": "2012-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32011R0286",
     "index": "028-047-00-2"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": null,
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "nickel difluoride [1]",
   "cas": "",
   "ec": "233-071-3 [1]",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "ATP02",
     "applies_from": "2012-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32011R0286",
     "index": "028-029-00-4"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/nickel_difluoride_[1]",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "nickel diformate [1]",
   "cas": "",
   "ec": "222-101-0 [1]",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "ATP02",
     "applies_from": "2012-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32011R0286",
     "index": "028-021-00-0"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/nickel_diformate_[1]",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "nickel dihydroxide [1]",
   "cas": "",
   "ec": "235-008-5 [1]",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "ATP01",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32009R0790",
     "index": "028-008-00-X"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/nickel_dihydroxide_[1]",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "nickel dilactate",
   "cas": "16039-61-5",
   "ec": "-",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "ATP02",
     "applies_from": "2012-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32011R0286",
     "index": "028-027-00-3"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": null,
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "nickel dinitrate [1]",
   "cas": "",
   "ec": "236-068-5 [1]",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "ATP01corr",
     "applies_from": "2013-08-13",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32013R0758",
     "index": "028-012-00-1"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/nickel_dinitrate_[1]",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "nickel diperchlorate; perchloric acid, nickel(II) salt",
   "cas": "13637-71-3",
   "ec": "237-124-1",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "ATP02",
     "applies_from": "2012-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32011R0286",
     "index": "028-016-00-3"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Nickel(II)_perchlorate",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "nickel dipotassium bis(sulfate) [1]",
   "cas": "",
   "ec": "237-563-9 [1]",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "ATP02",
     "applies_from": "2012-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32011R0286",
     "index": "028-017-00-9"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/nickel_dipotassium_bis(sulfate)_[1]",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "nickel dithiocyanate",
   "cas": "13689-92-4",
   "ec": "237-205-1",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "ATP02",
     "applies_from": "2012-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32011R0286",
     "index": "028-046-00-7"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Nickel(II)_thiocyanate",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "nickel hexafluorosilicate",
   "cas": "26043-11-8",
   "ec": "247-430-7",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "ATP02",
     "applies_from": "2012-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32011R0286",
     "index": "028-030-00-X"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": null,
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "nickel selenate",
   "cas": "15060-62-5",
   "ec": "239-125-2",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "ATP02",
     "applies_from": "2012-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32011R0286",
     "index": "028-031-00-5"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Nickel(II)_selenate",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "nickel sulfate",
   "cas": "7786-81-4",
   "ec": "232-104-9",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "ATP01corr",
     "applies_from": "2013-08-13",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32013R0758",
     "index": "028-009-00-5"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Nickel(II)_sulfate",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "nickel(II) octanoate",
   "cas": "4995-91-9",
   "ec": "225-656-7",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "ATP02",
     "applies_from": "2012-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32011R0286",
     "index": "028-028-00-9"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": null,
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "nickel(II) stearate; nickel(II) octadecanoate",
   "cas": "2223-95-2",
   "ec": "218-744-1",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "ATP02",
     "applies_from": "2012-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32011R0286",
     "index": "028-026-00-8"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Nickel(II)_stearate",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "nickel(II) trifluoroacetate [1]",
   "cas": "",
   "ec": "240-235-8 [1]",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "ATP02",
     "applies_from": "2012-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32011R0286",
     "index": "028-054-00-0"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/nickel(II)_trifluoroacetate_[1]",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "nitrofen (ISO); 2,4-dichlorophenyl 4-nitrophenyl ether",
   "cas": "1836-75-5",
   "ec": "217-406-0",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "CLP00",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "609-040-00-9"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Nitrofen",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "nonadecafluorodecanoic acid [1]",
   "cas": "",
   "ec": "206-400-3 [1]",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360Df"
     ],
     "developmental_specific": true,
     "atp": "ATP10",
     "applies_from": "2018-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32017R0776",
     "index": "607-720-00-X"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/nonadecafluorodecanoic_acid_[1]",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "pentapotassium 2,2',2\",2\"',2\"\"-(ethane-1,2-diylnitrilo)pentaacetate",
   "cas": "7216-95-7",
   "ec": "404-290-3",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "ATP18",
     "applies_from": "2023-11-23",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32022R0692",
     "index": "607-734-00-6"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": null,
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "pentasodium (carboxylatomethyl)iminobis(ethylenenitrilo)tetraacetate",
   "cas": "140-01-2",
   "ec": "205-391-3",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "ATP18",
     "applies_from": "2023-11-23",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32022R0692",
     "index": "607-736-00-7"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": null,
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "perboric acid (H3BO2(O2)), monosodium salt trihydrate [1]",
   "cas": "",
   "ec": "239-172-9 [1]",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360FD"
     ],
     "developmental_specific": true,
     "atp": "ATP22",
     "applies_from": "2026-05-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32024R2564",
     "index": "005-023-00-X"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": null,
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "perboric acid, sodium salt [1]",
   "cas": "",
   "ec": "234-390-0 [1]",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360FD"
     ],
     "developmental_specific": true,
     "atp": "ATP22",
     "applies_from": "2026-05-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32024R2564",
     "index": "005-022-00-4"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/perboric_acid,_sodium_salt_[1]",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "Perfluoroheptanoic acid; tridecafluoroheptanoic acid",
   "cas": "375-85-9",
   "ec": "206-798-9",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "ATP18",
     "applies_from": "2023-11-23",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32022R0692",
     "index": "607-761-00-3"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": null,
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "perfluorononan-1-oic acid [1]",
   "cas": "",
   "ec": "206-801-3 [1]",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360Df"
     ],
     "developmental_specific": true,
     "atp": "ATP09",
     "applies_from": "2018-03-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32016R1179",
     "index": "607-718-00-9"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/perfluorononan-1-oic_acid_[1]",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "perfluorooctane sulfonic acid; heptadecafluorooctane-1-sulfonic acid [1]",
   "cas": "",
   "ec": "217-179-8 [1]",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "ATP01",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32009R0790",
     "index": "607-624-00-8"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Perfluorooctanesulfonic_acid",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "pitch, coal tar, high-temp.; [The residue from the distillation of high temperature coal tar. A black solid with an approximate softening point from 30 °C to 180 °C (86 °F to 356 °F). Composed primarily of a complex mixture of three or more membered condensed ring aromatic hydrocarbons.]",
   "cas": "65996-93-2",
   "ec": "266-028-2",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360FD"
     ],
     "developmental_specific": true,
     "atp": "ATP14",
     "applies_from": "2019-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32020R0217",
     "index": "648-055-00-5"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": null,
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "Pomalidomide",
   "cas": "19171-19-8",
   "ec": "",
   "kind": "medicine",
   "sources": [
    {
     "label": "EMA: pregnancy prevention programme or contraindication for teratogenicity",
     "code": "ema",
     "note": "Thalidomide analogue (Imnovid): pregnancy prevention programme.",
     "url": "https://www.ema.europa.eu/en/medicines/human/EPAR/imnovid",
     "url_status": 200
    }
   ],
   "status": {
    "ema": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": "Authorised within a pregnancy prevention programme; contraindicated in pregnancy.",
    "USA": "Authorised under an FDA REMS programme."
   },
   "wiki": "https://en.wikipedia.org/wiki/Pomalidomide",
   "level": "presumed",
   "source_codes": [
    "ema"
   ]
  },
  {
   "name": "potassium 1-methyl-3-morpholinocarbonyl-4-[3-(1-methyl-3-morpholinocarbonyl-5-oxo-2-pyrazolin-4-ylidene)-1-propenyl]pyrazole-5-olate; [containing ≥ 0,5 % N,N-dimethylformamide (EC No 200-679-5)]",
   "cas": "183196-57-8",
   "ec": "418-260-2",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "ATP01",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32009R0790",
     "index": "613-286-01-X"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/potassium_1-methyl-3-morpholinocarbonyl-4-[3-(1-methyl-3-morpholinocarbonyl-5-oxo-2-pyrazolin-4-ylidene)-1-propenyl]pyrazole-5-olate",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "potassium dichromate",
   "cas": "7778-50-9",
   "ec": "231-906-6",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360FD"
     ],
     "developmental_specific": true,
     "atp": "CLP00",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "024-002-00-6"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Potassium_dichromate",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "propiconazole (ISO); (2RS,4RS;2RS,4SR)-1-{[2-(2,4-dichlorophenyl)-4-propyl-1,3-dioxolan-2-yl]methyl}-1H-1,2,4-triazole",
   "cas": "60207-90-1",
   "ec": "262-104-4",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "ATP13",
     "applies_from": "2020-05-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32018R1480",
     "index": "613-205-00-0"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Propiconazole",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "pyrithione zinc; (T-4)-bis[1-(hydroxy-.kappa.O)pyridine-2(1H)-thionato-.kappa.S]zinc",
   "cas": "13463-41-7",
   "ec": "236-671-3",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "ATP15",
     "applies_from": "2022-03-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32020R1182",
     "index": "613-333-00-7"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Zinc_pyrithione",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "quinolin-8-ol; 8-hydroxyquinoline",
   "cas": "148-24-3",
   "ec": "205-711-1",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "ATP10",
     "applies_from": "2018-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32017R0776",
     "index": "613-324-00-8"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/8-Hydroxyquinoline",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "reaction mass of 1,3-dioxan-5-ol and 1,3-dioxolan-4-ylmethanol",
   "cas": "",
   "ec": "-",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360Df"
     ],
     "developmental_specific": true,
     "atp": "ATP22",
     "applies_from": "2026-05-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32024R2564",
     "index": "603-247-00-8"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": null,
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "Reaction mass of 3-(difluoromethyl)-1-methyl-N-[(1RS,4SR,9RS)-1,2,3,4-tetrahydro-9-isopropyl-1,4-methanonaphthalen-5-yl]pyrazole-4-carboxamide and 3-(difluoromethyl)-1-methyl-N-[(1RS,4SR,9SR)-1,2,3,4-tetrahydro-9-isopropyl-1,4-methanonaphthalen-5-yl]pyrazole-4-carboxamide [≥ 78 % syn isomers ≤ 15 % anti isomers relative content]; isopyrazam",
   "cas": "881685-58-1",
   "ec": "-",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "ATP18",
     "applies_from": "2023-11-23",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32022R0692",
     "index": "616-240-00-X"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Reaction_mass_of_3-(difluoromethyl)-1-methyl-N-[(1RS,4SR,9RS)-1,2,3,4-tetrahydro-9-isopropyl-1,4-methanonaphthalen-5-yl]pyrazole-4-carboxamide_and_3-(difluoromethyl)-1-methyl-N-[(1RS,4SR,9SR)-1,2,3,4-tetrahydro-9-isopropyl-1,4-methanonaphthalen-5-yl]pyrazole-4-carboxamide_[≥_78_%_syn_isomers_≤_15_%_anti_isomers_relative_content]",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "reaction mass of: 1,3,5-tris(3-aminomethylphenyl)-1,3,5-(1H,3H,5H)-triazine-2,4,6-trione; reaction mass of oligomers of 3,5-bis(3-aminomethylphenyl)-1-poly[3,5-bis(3-aminomethylphenyl)-2,4,6-trioxo-1,3,5-(1H,3H,5H)-triazin-1-yl]-1,3,5-(1H,3H,5H)-triazine-2,4,6-trione",
   "cas": "",
   "ec": "421-550-1",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "CLP00",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "613-199-00-X"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": null,
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "reaction mass of: 4-[[bis-(4-fluorophenyl)methylsilyl]methyl]-4H-1,2,4-triazole; 1-[[bis-(4-fluorophenyl)methylsilyl]methyl]-1H-1,2,4-triazole",
   "cas": "",
   "ec": "403-250-2",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "CLP00",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "014-019-00-7"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/reaction_mass_of:_4-[[bis-(4-fluorophenyl)methylsilyl]methyl]-4H-1,2,4-triazole",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "reaction mass of: disodium 4-(3-ethoxycarbonyl-4-(5-(3-ethoxycarbonyl-5-hydroxy-1-(4-sulfonatophenyl)pyrazol-4-yl)penta-2,4-dienylidene)-4,5-dihydro-5-oxopyrazol-1-yl)benzenesulfonate; trisodium 4-(3-ethoxycarbonyl-4-(5-(3-ethoxycarbonyl-5-oxido-1-(4-sulfonatophenyl)pyrazol-4-yl)penta-2,4-dienylidene)-4,5-dihydro-5-oxopyrazol-1-yl)benzenesulfonate",
   "cas": "",
   "ec": "402-660-9",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "CLP00",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "607-487-00-4"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": null,
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "salts and esters of dinoseb, with the exception of those specified elsewhere in this Annex",
   "cas": "",
   "ec": "-",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360Df"
     ],
     "developmental_specific": true,
     "atp": "CLP00",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "609-026-00-2"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": null,
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "salts and esters of dinoterb",
   "cas": "",
   "ec": "-",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "CLP00",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "609-031-00-X"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": null,
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "slimes and sludges, copper electrolytic refining, decopperised, nickel sulfate",
   "cas": "92129-57-2",
   "ec": "295-859-3",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "ATP01",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32009R0790",
     "index": "028-014-00-2"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": null,
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "sodium chromate",
   "cas": "7775-11-3",
   "ec": "231-889-5",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360FD"
     ],
     "developmental_specific": true,
     "atp": "CLP00",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "024-018-00-3"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Sodium_chromate",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "sodium dichromate",
   "cas": "10588-01-9",
   "ec": "234-190-3",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360FD"
     ],
     "developmental_specific": true,
     "atp": "ATP01corr",
     "applies_from": "2013-08-13",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32013R0758",
     "index": "024-004-00-7"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Sodium_dichromate",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "sodium peroxometaborate",
   "cas": "7632-04-4",
   "ec": "231-556-4",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360FD"
     ],
     "developmental_specific": true,
     "atp": "ATP22",
     "applies_from": "2026-05-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32024R2564",
     "index": "005-024-00-5"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": null,
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "tellurium",
   "cas": "13494-80-9",
   "ec": "236-813-4",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360Df"
     ],
     "developmental_specific": true,
     "atp": "ATP18",
     "applies_from": "2023-11-23",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32022R0692",
     "index": "052-001-00-0"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Tellurium",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "tellurium dioxide",
   "cas": "7446-07-3",
   "ec": "231-193-1",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360Df"
     ],
     "developmental_specific": true,
     "atp": "ATP18",
     "applies_from": "2023-11-23",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32022R0692",
     "index": "052-002-00-6"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Tellurium_dioxide",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "tert-butyl 2-ethylperoxyhexanoate",
   "cas": "3006-82-4",
   "ec": "221-110-7",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360FD"
     ],
     "developmental_specific": true,
     "atp": "ATP22",
     "applies_from": "2026-05-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32024R2564",
     "index": "617-024-00-8"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": null,
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "tetraboron disodium heptaoxide, hydrate [1]",
   "cas": "",
   "ec": "235-541-3 [1]",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360FD"
     ],
     "developmental_specific": true,
     "atp": "ATP20",
     "applies_from": "2025-02-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32023R1435",
     "index": "005-011-00-4"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/tetraboron_disodium_heptaoxide,_hydrate_[1]",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "tetrahydro-2-furylmethanol; tetrahydrofurfuryl alcohol",
   "cas": "97-99-4",
   "ec": "202-625-6",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360Df"
     ],
     "developmental_specific": true,
     "atp": "ATP06",
     "applies_from": "2015-04-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32014R0605",
     "index": "603-061-00-7"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Tetrahydrofurfuryl_alcohol",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "tetrahydrofurfuryl methacrylate",
   "cas": "2455-24-5",
   "ec": "219-529-5",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360Df"
     ],
     "developmental_specific": true,
     "atp": "ATP23",
     "applies_from": "2027-02-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32025R1222",
     "index": "607-778-00-6"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": null,
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "tetrahydrothiopyran-3-carboxaldehyde",
   "cas": "61571-06-0",
   "ec": "407-330-8",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "CLP00",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "606-062-00-0"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": null,
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "theophylline; 1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione",
   "cas": "58-55-9",
   "ec": "200-385-7",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "ATP18",
     "applies_from": "2023-11-23",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32022R0692",
     "index": "613-342-00-6"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Theophylline",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "thiacloprid (ISO); (Z)-3-(6-chloro-3-pyridylmethyl)-1,3-thiazolidin-2-ylidenecyanamide; {(2Z)-3-[(6-chloropyridin-3-yl)methyl]-1,3-thiazolidin-2-ylidene}cyanamide",
   "cas": "111988-49-9",
   "ec": "-",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360FD"
     ],
     "developmental_specific": true,
     "atp": "ATP10",
     "applies_from": "2018-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32017R0776",
     "index": "613-325-00-3"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Thiacloprid",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "triadimenol (ISO); (1RS,2RS;1RS,2SR)-1-(4-chlorophenoxy)-3,3-dimethyl-1-(1H-1,2,4-triazol-1-yl)butan-2-ol; α-tert-butyl-β-(4-chlorophenoxy)-1H-1,2,4-triazole-1-ethanol",
   "cas": "55219-65-3",
   "ec": "259-537-6",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360"
     ],
     "developmental_specific": false,
     "atp": "ATP10",
     "applies_from": "2018-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32017R0776",
     "index": "613-322-00-7"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": null,
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "tributyltin compounds, with the exception of those specified elsewhere in this annex",
   "cas": "",
   "ec": "-",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360FD"
     ],
     "developmental_specific": true,
     "atp": "ATP07",
     "applies_from": "2017-01-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32015R1221",
     "index": "050-008-00-3"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": null,
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "tridemorph (ISO); 2,6-dimethyl-4-tridecylmorpholine",
   "cas": "24602-86-6",
   "ec": "246-347-3",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "CLP00",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "613-020-00-5"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Tridemorph",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "triflumizole (ISO); (1E)-N-[4-chloro-2-(trifluoromethyl)phenyl]-1-(1H-imidazol-1-yl)-2-propoxyethanimine",
   "cas": "68694-11-1",
   "ec": "-",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360D"
     ],
     "developmental_specific": true,
     "atp": "ATP09",
     "applies_from": "2018-03-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32016R1179",
     "index": "612-289-00-6"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": null,
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "trimethyl borate",
   "cas": "121-43-7",
   "ec": "204-468-9",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360FD"
     ],
     "developmental_specific": true,
     "atp": "ATP22",
     "applies_from": "2026-05-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32024R2564",
     "index": "005-005-00-1"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Trimethyl_borate",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "trimethyl phosphate",
   "cas": "512-56-1",
   "ec": "208-144-8",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360FD"
     ],
     "developmental_specific": true,
     "atp": "ATP23",
     "applies_from": "2027-02-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32025R1222",
     "index": "015-209-00-2"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Trimethyl_phosphate",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "tris(2-methoxyethoxy)vinylsilane; 6-(2-methoxyethoxy)-6-vinyl-2,5,7,10-tetraoxa-6-silaundecane",
   "cas": "1067-53-4",
   "ec": "213-934-0",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360FD"
     ],
     "developmental_specific": true,
     "atp": "ATP15",
     "applies_from": "2022-03-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32020R1182",
     "index": "014-050-00-6"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": null,
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "α,α-propylenedinitrilodi-o-cresol",
   "cas": "94-91-7",
   "ec": "202-374-2",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 1B",
     "statements": [
      "H360FD"
     ],
     "developmental_specific": true,
     "atp": "ATP23",
     "applies_from": "2027-02-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32025R1222",
     "index": "604-103-00-7"
    }
   ],
   "status": {
    "clp": "presumed"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Not to be supplied to the general public as a substance or in mixtures above the concentration limit (REACH Annex XVII, entry 30, where listed in Appendix 5 or 6).",
     "pesticides": "Cannot be approved as a pesticide active substance unless human exposure is negligible (Regulation 1107/2009, Annex II 3.6.4).",
     "cosmetics": "Prohibited in cosmetic products (Regulation 1223/2009, Article 15).",
     "work": "Reprotoxic substance under Directive 2004/37/EC as amended by Directive 2022/431: substitution, exposure limits and health surveillance at work."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Salpn_ligand",
   "level": "presumed",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "(RS)-1-{1-ethyl-4-[4-mesyl-3-(2-methoxyethoxy)-o-toluoyl]pyrazol-5-yloxy}ethyl methyl carbonate; tolpyralate",
   "cas": "1101132-67-5",
   "ec": "-",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361fd"
     ],
     "developmental_specific": true,
     "atp": "ATP17",
     "applies_from": "2022-12-17",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32021R0849",
     "index": "607-755-00-0"
    }
   ],
   "status": {
    "clp": "suspected"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/(RS)-1-{1-ethyl-4-[4-mesyl-3-(2-methoxyethoxy)-o-toluoyl]pyrazol-5-yloxy}ethyl_methyl_carbonate",
   "level": "suspected",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "1,3,5-trioxan; trioxymethylene",
   "cas": "110-88-3",
   "ec": "203-812-5",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361d"
     ],
     "developmental_specific": true,
     "atp": "CLP00",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "605-002-00-0"
    }
   ],
   "status": {
    "clp": "suspected"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/1,3,5-Trioxane",
   "level": "suspected",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "2-ethylhexyl 10-ethyl-4,4-dimethyl-7-oxo-8-oxa-3,5-dithia-4-stannatetradecanoate",
   "cas": "57583-35-4",
   "ec": "260-829-0",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361d"
     ],
     "developmental_specific": true,
     "atp": "ATP06",
     "applies_from": "2015-04-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32014R0605",
     "index": "050-028-00-2"
    }
   ],
   "status": {
    "clp": "suspected"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    }
   },
   "wiki": null,
   "level": "suspected",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "2-ethylhexyl 10-ethyl-4-[[2-[(2-ethylhexyl)oxy]-2-oxoethyl]thio]-4-methyl-7-oxo-8-oxa-3,5-dithia-4-stannatetradecanoate",
   "cas": "57583-34-3",
   "ec": "260-828-5",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361d"
     ],
     "developmental_specific": true,
     "atp": "ATP05",
     "applies_from": "2015-01-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32013R0944",
     "index": "050-026-00-1"
    }
   ],
   "status": {
    "clp": "suspected"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/2-ethylhexyl_10-ethyl-4-[[2-[(2-ethylhexyl)oxy]-2-oxoethyl]thio]-4-methyl-7-oxo-8-oxa-3,5-dithia-4-stannatetradecanoate",
   "level": "suspected",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "2-ethylhexyl-2-ethylhexanoate",
   "cas": "7425-14-1",
   "ec": "231-057-1",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361d"
     ],
     "developmental_specific": true,
     "atp": "ATP01",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32009R0790",
     "index": "607-622-00-7"
    }
   ],
   "status": {
    "clp": "suspected"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    }
   },
   "wiki": null,
   "level": "suspected",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "2-methyl-5-tert-butylthiophenol",
   "cas": "",
   "ec": "444-970-7",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361d"
     ],
     "developmental_specific": true,
     "atp": "ATP01",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32009R0790",
     "index": "604-089-00-2"
    }
   ],
   "status": {
    "clp": "suspected"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    }
   },
   "wiki": null,
   "level": "suspected",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "abamectin (combination of avermectin B1a and avermectin B1b) (ISO) [1]",
   "cas": "",
   "ec": "- [1]",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361d"
     ],
     "developmental_specific": true,
     "atp": "ATP03",
     "applies_from": "2013-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32012R0618",
     "index": "606-143-00-0"
    }
   ],
   "status": {
    "clp": "suspected"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Abamectin",
   "level": "suspected",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "acetamiprid (ISO); (1E)-N-[(6-chloropyridin-3-yl)methyl]-N-cyano-N-methylethanimidamide; (E)-N1-[(6-chloro-3-pyridyl)methyl]-N2-cyano-N1-methylacetamidine [1]",
   "cas": "",
   "ec": "- [1]",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361d"
     ],
     "developmental_specific": true,
     "atp": "ATP18",
     "applies_from": "2023-11-23",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32022R0692",
     "index": "608-032-00-2"
    }
   ],
   "status": {
    "clp": "suspected"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Acetamiprid",
   "level": "suspected",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "amitrole (ISO); 1,2,4-triazol-3-ylamine",
   "cas": "61-82-5",
   "ec": "200-521-5",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361d"
     ],
     "developmental_specific": true,
     "atp": "CLP00",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "613-011-00-6"
    }
   ],
   "status": {
    "clp": "suspected"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/3-Amino-1,2,4-triazole",
   "level": "suspected",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "benfluralin (ISO); N-butyl-N-ethyl-α,α,α-trifluoro-2,6-dinitro-p-toluidine",
   "cas": "1861-40-1",
   "ec": "217-465-2",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361d"
     ],
     "developmental_specific": true,
     "atp": "ATP21",
     "applies_from": "2025-09-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32024R0197",
     "index": "612-295-00-9"
    }
   ],
   "status": {
    "clp": "suspected"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Benfluralin",
   "level": "suspected",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "bentazone (ISO); 3-isopropyl-2,1,3-benzothiadiazine-4-one-2,2-dioxide",
   "cas": "25057-89-0",
   "ec": "246-585-8",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361d"
     ],
     "developmental_specific": true,
     "atp": "ATP18",
     "applies_from": "2023-11-23",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32022R0692",
     "index": "613-012-00-1"
    }
   ],
   "status": {
    "clp": "suspected"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Bentazon",
   "level": "suspected",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "benthiavalicarb-isopropyl (ISO); isopropyl [(S)-1-{[(R)-1-(6-fluoro-1,3-benzothiazol-2-yl)ethyl]carbamoyl}-2-methylpropyl]carbamate",
   "cas": "177406-68-7",
   "ec": "-",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361fd"
     ],
     "developmental_specific": true,
     "atp": "ATP22",
     "applies_from": "2026-05-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32024R2564",
     "index": "607-771-00-8"
    }
   ],
   "status": {
    "clp": "suspected"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    }
   },
   "wiki": null,
   "level": "suspected",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "bromoxynil heptanoate (ISO); 2,6-dibromo-4-cyanophenyl heptanoate",
   "cas": "56634-95-8",
   "ec": "260-300-4",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361d"
     ],
     "developmental_specific": true,
     "atp": "CLP00",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "607-427-00-7"
    }
   ],
   "status": {
    "clp": "suspected"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    }
   },
   "wiki": null,
   "level": "suspected",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "butroxydim (ISO); 5-(3-butyryl-2,4,6-trimethylphenyl)-2-[1-(ethoxyimino)propyl]-3-hydroxycyclohex-2-en-1-one",
   "cas": "138164-12-2",
   "ec": "414-790-3",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361fd"
     ],
     "developmental_specific": true,
     "atp": "CLP00",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "606-070-00-4"
    }
   ],
   "status": {
    "clp": "suspected"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Butroxydim",
   "level": "suspected",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "cadmium (non-pyrophoric) [1]",
   "cas": "",
   "ec": "231-152-8 [1]",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361fd"
     ],
     "developmental_specific": true,
     "atp": "CLP00",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "048-002-00-0"
    }
   ],
   "status": {
    "clp": "suspected"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Cadmium",
   "level": "suspected",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "cadmium (pyrophoric)",
   "cas": "7440-43-9",
   "ec": "231-152-8",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361fd"
     ],
     "developmental_specific": true,
     "atp": "CLP00",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "048-011-00-X"
    }
   ],
   "status": {
    "clp": "suspected"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Cadmium",
   "level": "suspected",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "cadmium sulphide",
   "cas": "1306-23-6",
   "ec": "215-147-8",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361fd"
     ],
     "developmental_specific": true,
     "atp": "CLP00",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "048-010-00-4"
    }
   ],
   "status": {
    "clp": "suspected"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Cadmium_sulfide",
   "level": "suspected",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "chlorotoluron (ISO); 3-(3-chloro-p-tolyl)-1,1-dimethylurea",
   "cas": "15545-48-9",
   "ec": "239-592-2",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361d"
     ],
     "developmental_specific": true,
     "atp": "CLP00",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "616-105-00-5"
    }
   ],
   "status": {
    "clp": "suspected"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Chlortoluron",
   "level": "suspected",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "cis-1-(3-chloroallyl)-3,5,7-triaza-1-azoniaadamantane chloride",
   "cas": "51229-78-8",
   "ec": "426-020-3",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361d"
     ],
     "developmental_specific": true,
     "atp": "ATP01",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32009R0790",
     "index": "612-251-00-9"
    }
   ],
   "status": {
    "clp": "suspected"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Quaternium-15",
   "level": "suspected",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "cyanamide; carbamonitril",
   "cas": "420-04-2",
   "ec": "206-992-3",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361fd"
     ],
     "developmental_specific": true,
     "atp": "ATP10",
     "applies_from": "2018-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32017R0776",
     "index": "615-013-00-2"
    }
   ],
   "status": {
    "clp": "suspected"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Cyanamide",
   "level": "suspected",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "cycloxydim (ISO); 2-(N-ethoxybutanimidoyl)-3-hydroxy-5-(tetrahydro-2H-thiopyran-3-yl)cyclohex-2-en-1-one",
   "cas": "101205-02-1",
   "ec": "405-230-9",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361d"
     ],
     "developmental_specific": true,
     "atp": "ATP06",
     "applies_from": "2015-04-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32014R0605",
     "index": "606-147-00-2"
    }
   ],
   "status": {
    "clp": "suspected"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    }
   },
   "wiki": null,
   "level": "suspected",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "cymoxanil (ISO); 2-cyano-N-[(ethylamino)carbonyl]-2-(methoxyimino)acetamide [1]",
   "cas": "",
   "ec": "261-043-0 [1]",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361fd"
     ],
     "developmental_specific": true,
     "atp": "ATP21",
     "applies_from": "2025-09-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32024R0197",
     "index": "616-035-00-5"
    }
   ],
   "status": {
    "clp": "suspected"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    }
   },
   "wiki": null,
   "level": "suspected",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "desmedipham (ISO); ethyl 3-phenylcarbamoyloxyphenylcarbamate",
   "cas": "13684-56-5",
   "ec": "237-198-5",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361d"
     ],
     "developmental_specific": true,
     "atp": "ATP17",
     "applies_from": "2022-12-17",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32021R0849",
     "index": "616-113-00-9"
    }
   ],
   "status": {
    "clp": "suspected"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    }
   },
   "wiki": null,
   "level": "suspected",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "dimethyltin dichloride",
   "cas": "753-73-1",
   "ec": "212-039-2",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361d"
     ],
     "developmental_specific": true,
     "atp": "ATP06",
     "applies_from": "2015-04-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32014R0605",
     "index": "050-029-00-8"
    }
   ],
   "status": {
    "clp": "suspected"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Dimethyltin_dichloride",
   "level": "suspected",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "dimoxystrobin (ISO); (2E)-2-{2-[(2,5-dimethylphenoxy)methyl]phenyl}-2-(methoxyimino)-N-methylacetamide; (E)-2-(methoxyimino)-N-methyl-2-[α-(2,5-xylyloxy)-o-tolyl]acetamide",
   "cas": "149961-52-4",
   "ec": "-",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361d"
     ],
     "developmental_specific": true,
     "atp": "ATP18",
     "applies_from": "2023-11-23",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32022R0692",
     "index": "616-164-00-7"
    }
   ],
   "status": {
    "clp": "suspected"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    }
   },
   "wiki": null,
   "level": "suspected",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "disodium 3,3'-[[1,1'-biphenyl]-4,4'-diylbis(azo)]bis(4-aminonaphthalene-1-sulphonate); C.I. Direct Red 28",
   "cas": "573-58-0",
   "ec": "209-358-4",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361d"
     ],
     "developmental_specific": true,
     "atp": "CLP00",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "611-027-00-8"
    }
   ],
   "status": {
    "clp": "suspected"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Congo_red",
   "level": "suspected",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "disodium 4-amino-3-[[4'-[(2,4-diaminophenyl)azo][1,1'-biphenyl]-4-yl]azo]-5-hydroxy-6-(phenylazo)naphtalene-2,7-disulphonate; C.I. Direct Black 38",
   "cas": "1937-37-7",
   "ec": "217-710-3",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361d"
     ],
     "developmental_specific": true,
     "atp": "CLP00",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "611-025-00-7"
    }
   ],
   "status": {
    "clp": "suspected"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/disodium_4-amino-3-[[4'-[(2,4-diaminophenyl)azo][1,1'-biphenyl]-4-yl]azo]-5-hydroxy-6-(phenylazo)naphtalene-2,7-disulphonate",
   "level": "suspected",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "divanadium pentaoxide; vanadium pentoxide",
   "cas": "1314-62-1",
   "ec": "215-239-8",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361fd"
     ],
     "developmental_specific": true,
     "atp": "ATP18",
     "applies_from": "2023-11-23",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32022R0692",
     "index": "023-001-00-8"
    }
   ],
   "status": {
    "clp": "suspected"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Vanadium(V)_oxide",
   "level": "suspected",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "dodecachloropentacyclo[5.2.1.02,6.03,9.05,8]decane; mirex",
   "cas": "2385-85-5",
   "ec": "219-196-6",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361fd"
     ],
     "developmental_specific": true,
     "atp": "CLP00",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "602-077-00-1"
    }
   ],
   "status": {
    "clp": "suspected"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Mirex",
   "level": "suspected",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "dodemorph (ISO); 4-cyclododecyl-2,6-dimethylmorpholine",
   "cas": "1593-77-7",
   "ec": "216-474-9",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361d"
     ],
     "developmental_specific": true,
     "atp": "ATP07",
     "applies_from": "2017-01-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32015R1221",
     "index": "613-057-00-7"
    }
   ],
   "status": {
    "clp": "suspected"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    }
   },
   "wiki": null,
   "level": "suspected",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "dodemorph acetate; 4-cyclododecyl-2,6-dimethylmorpholin-4-ium acetate",
   "cas": "31717-87-0",
   "ec": "250-778-2",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361d"
     ],
     "developmental_specific": true,
     "atp": "ATP07",
     "applies_from": "2017-01-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32015R1221",
     "index": "607-712-00-6"
    }
   ],
   "status": {
    "clp": "suspected"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    }
   },
   "wiki": null,
   "level": "suspected",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "fenarimol (ISO); 2,4'-dichloro-α-(pyrimidin-5-yl)benzhydryl alcohol",
   "cas": "60168-88-9",
   "ec": "262-095-7",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361fd"
     ],
     "developmental_specific": true,
     "atp": "CLP00",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "603-104-00-X"
    }
   ],
   "status": {
    "clp": "suspected"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Fenarimol",
   "level": "suspected",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "fenpropidin (ISO); (R,S)-1-[3-(4-tert-butylphenyl)-2-methylpropyl]piperidine",
   "cas": "67306-00-7",
   "ec": "-",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361d"
     ],
     "developmental_specific": true,
     "atp": "ATP22",
     "applies_from": "2026-05-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32024R2564",
     "index": "612-299-00-0"
    }
   ],
   "status": {
    "clp": "suspected"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    }
   },
   "wiki": null,
   "level": "suspected",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "fenpropimorph (ISO); cis-4-[3-(p-tert-butylphenyl)-2-methylpropyl]-2,6-dimethylmorpholine",
   "cas": "67564-91-4",
   "ec": "266-719-9",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361d"
     ],
     "developmental_specific": true,
     "atp": "CLP00",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "613-124-00-0"
    }
   ],
   "status": {
    "clp": "suspected"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Fenpropimorph",
   "level": "suspected",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "fentin acetate (ISO); triphenyltin acetate",
   "cas": "900-95-8",
   "ec": "212-984-0",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361d"
     ],
     "developmental_specific": true,
     "atp": "ATP01",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32009R0790",
     "index": "050-003-00-6"
    }
   ],
   "status": {
    "clp": "suspected"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Fentin_acetate",
   "level": "suspected",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "fluazifop-P-butyl (ISO); butyl (R)-2-[4-(5-trifluoromethyl-2-pyridyloxy)phenoxy]propionate",
   "cas": "79241-46-6",
   "ec": "-",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361d"
     ],
     "developmental_specific": true,
     "atp": "CLP00",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "607-305-00-3"
    }
   ],
   "status": {
    "clp": "suspected"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Fluazifop",
   "level": "suspected",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "fluazinam (ISO); 3-chloro-N-[3-chloro-2,6-dinitro-4-(trifluoromethyl)phenyl]-5-(trifluoromethyl)pyridin-2-amine",
   "cas": "79622-59-6",
   "ec": "-",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361d"
     ],
     "developmental_specific": true,
     "atp": "ATP06",
     "applies_from": "2015-04-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32014R0605",
     "index": "612-287-00-5"
    }
   ],
   "status": {
    "clp": "suspected"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Fluazinam",
   "level": "suspected",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "flumioxazin (ISO); N-(7-fluoro-3,4-dihydro-3-oxo-4-prop-2-ynyl-2H-1,4-benzoxazin-6-yl)cyclohex-1-ene-1,2-dicarboximide",
   "cas": "103361-09-7",
   "ec": "-",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361d"
     ],
     "developmental_specific": true,
     "atp": "ATP17",
     "applies_from": "2022-12-17",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32021R0849",
     "index": "613-166-00-X"
    }
   ],
   "status": {
    "clp": "suspected"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Flumioxazin",
   "level": "suspected",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "fluopicolide (ISO); 2,6-dichloro-N-[3-chloro-5-(trifluoromethyl)-2-pyridylmethyl]benzamide",
   "cas": "239110-15-7",
   "ec": "-",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361d"
     ],
     "developmental_specific": true,
     "atp": "ATP18",
     "applies_from": "2023-11-23",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32022R0692",
     "index": "616-237-00-3"
    }
   ],
   "status": {
    "clp": "suspected"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Fluopicolide",
   "level": "suspected",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "Hexabromocyclododecane [1]",
   "cas": "",
   "ec": "247-148-4 [1]",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361"
     ],
     "developmental_specific": false,
     "atp": "ATP03",
     "applies_from": "2013-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32012R0618",
     "index": "602-109-00-4"
    }
   ],
   "status": {
    "clp": "suspected"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Hexabromocyclododecane_[1]",
   "level": "suspected",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "hexyl salicylate",
   "cas": "6259-76-3",
   "ec": "228-408-6",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361d"
     ],
     "developmental_specific": true,
     "atp": "ATP22",
     "applies_from": "2026-05-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32024R2564",
     "index": "607-772-00-3"
    }
   ],
   "status": {
    "clp": "suspected"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    }
   },
   "wiki": null,
   "level": "suspected",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "hymexazol (ISO); 3-hydroxy-5-methylisoxazole",
   "cas": "10004-44-1",
   "ec": "233-000-6",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361d"
     ],
     "developmental_specific": true,
     "atp": "ATP15",
     "applies_from": "2022-03-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32020R1182",
     "index": "613-115-00-1"
    }
   ],
   "status": {
    "clp": "suspected"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    }
   },
   "wiki": null,
   "level": "suspected",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "imazamox (ISO); (RS)-2-(4-isopropyl-4-methyl-5-oxo-2-imidazolin-2-yl)-5-methoxymethylnicotinic acid",
   "cas": "114311-32-9",
   "ec": "-",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361d"
     ],
     "developmental_specific": true,
     "atp": "ATP17",
     "applies_from": "2022-12-17",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32021R0849",
     "index": "613-208-00-7"
    }
   ],
   "status": {
    "clp": "suspected"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    }
   },
   "wiki": null,
   "level": "suspected",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "ioxynil (ISO); 4-hydroxy-3,5-diiodobenzonitrile",
   "cas": "1689-83-4",
   "ec": "216-881-1",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361d"
     ],
     "developmental_specific": true,
     "atp": "CLP00",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "608-007-00-6"
    }
   ],
   "status": {
    "clp": "suspected"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Ioxynil",
   "level": "suspected",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "ioxynil octanoate (ISO); 4-cyano-2,6-diiodophenyl octanoate",
   "cas": "3861-47-0",
   "ec": "223-375-4",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361d"
     ],
     "developmental_specific": true,
     "atp": "CLP00",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "608-018-00-6"
    }
   ],
   "status": {
    "clp": "suspected"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Ioxynil_octanoate",
   "level": "suspected",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "isoxaflutole (ISO); 5-cyclopropyl-1,2-oxazol-4-yl α,α,α-trifluoro-2-mesyl-p-tolyl ketone",
   "cas": "141112-29-0",
   "ec": "-",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361d"
     ],
     "developmental_specific": true,
     "atp": "ATP07",
     "applies_from": "2017-01-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32015R1221",
     "index": "606-054-00-7"
    }
   ],
   "status": {
    "clp": "suspected"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Isoxaflutole",
   "level": "suspected",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "malachite green hydrochloride [1]",
   "cas": "",
   "ec": "209-322-8 [1]",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361d"
     ],
     "developmental_specific": true,
     "atp": "CLP00",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "602-096-00-5"
    }
   ],
   "status": {
    "clp": "suspected"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/malachite_green_hydrochloride_[1]",
   "level": "suspected",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "maneb (ISO); manganese ethylenebis(dithiocarbamate) (polymeric)",
   "cas": "12427-38-2",
   "ec": "235-654-8",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361d"
     ],
     "developmental_specific": true,
     "atp": "ATP01",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32009R0790",
     "index": "006-077-00-7"
    }
   ],
   "status": {
    "clp": "suspected"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Maneb",
   "level": "suspected",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "Margosa, ext. [from the kernels of Azadirachta indica extracted with water and further processed with organic solvents]",
   "cas": "84696-25-3",
   "ec": "283-644-7",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361d"
     ],
     "developmental_specific": true,
     "atp": "ATP18",
     "applies_from": "2023-11-23",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32022R0692",
     "index": "650-058-00-1"
    }
   ],
   "status": {
    "clp": "suspected"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Margosa,_ext._[from_the_kernels_of_Azadirachta_indica_extracted_with_water_and_further_processed_with_organic_solvents]",
   "level": "suspected",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "mesotrione (ISO); 2-[4-(methylsulfonyl)-2-nitrobenzoyl]-1,3-cyclohexanedione",
   "cas": "104206-82-8",
   "ec": "-",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361d"
     ],
     "developmental_specific": true,
     "atp": "ATP15",
     "applies_from": "2022-03-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32020R1182",
     "index": "609-064-00-X"
    }
   ],
   "status": {
    "clp": "suspected"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Mesotrione",
   "level": "suspected",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "metaflumizone (ISO); (EZ)-2-[2-(4-cyanophenyl)-1-(α,α,α -trifluoro-m-tolyl)ethylidene]-[4-(trifluoromethoxy)phenyl]carbanilohydrazide [E-isomer ≥ 90 %, Z-isomer ≤ 10 % relative content] [1]",
   "cas": "",
   "ec": "- [1]",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361fd"
     ],
     "developmental_specific": true,
     "atp": "ATP14",
     "applies_from": "2021-09-09",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32020R0217",
     "index": "616-227-00-9"
    }
   ],
   "status": {
    "clp": "suspected"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Metaflumizone",
   "level": "suspected",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "metconazole (ISO); (1RS, 5RS;1RS, 5SR)-5-(4-chlorobenzyl)-2,2-dimethyl-1-(1H-1,2,4-triazol-1-ylmethyl)cyclopentanol",
   "cas": "125116-23-6",
   "ec": "-",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361d"
     ],
     "developmental_specific": true,
     "atp": "ATP01",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32009R0790",
     "index": "613-284-00-1"
    }
   ],
   "status": {
    "clp": "suspected"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    }
   },
   "wiki": null,
   "level": "suspected",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "methyl salicylate",
   "cas": "119-36-8",
   "ec": "204-317-7",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361d"
     ],
     "developmental_specific": true,
     "atp": "ATP17",
     "applies_from": "2022-12-17",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32021R0849",
     "index": "607-749-00-8"
    }
   ],
   "status": {
    "clp": "suspected"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Methyl_salicylate",
   "level": "suspected",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "nonylphenol [1]",
   "cas": "",
   "ec": "246-672-0 [1]",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361fd"
     ],
     "developmental_specific": true,
     "atp": "CLP00",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "601-053-00-8"
    }
   ],
   "status": {
    "clp": "suspected"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/nonylphenol_[1]",
   "level": "suspected",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "oxadiargyl (ISO); 3-[2,4-dichloro-5-(2-propynyloxy)phenyl]-5-(1,1-dimethylethyl)-1,3,4-oxadiazol-2(3H)-one",
   "cas": "39807-15-3",
   "ec": "254-637-6",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361d"
     ],
     "developmental_specific": true,
     "atp": "ATP01corr",
     "applies_from": "2013-08-13",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32013R0758",
     "index": "613-204-00-5"
    }
   ],
   "status": {
    "clp": "suspected"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    }
   },
   "wiki": null,
   "level": "suspected",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "paclobutrazol (ISO); (2RS,3RS)-1-(4-chlorophenyl)-4,4-dimethyl-2-(1H-1,2,4-triazol-1-yl)pentan-3-ol",
   "cas": "76738-62-0",
   "ec": "-",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361d"
     ],
     "developmental_specific": true,
     "atp": "ATP15",
     "applies_from": "2022-03-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32020R1182",
     "index": "603-239-00-4"
    }
   ],
   "status": {
    "clp": "suspected"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Paclobutrazol",
   "level": "suspected",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "penconazole (ISO); 1-[2-(2,4-dichlorophenyl)pentyl]-1H-1,2,4-triazole",
   "cas": "66246-88-6",
   "ec": "266-275-6",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361d"
     ],
     "developmental_specific": true,
     "atp": "ATP06",
     "applies_from": "2015-04-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32014R0605",
     "index": "613-317-00-X"
    }
   ],
   "status": {
    "clp": "suspected"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    }
   },
   "wiki": null,
   "level": "suspected",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "pendimethalin (ISO); N-(1-ethylpropyl)-2,6-dinitro-3,4-xylidene",
   "cas": "40487-42-1",
   "ec": "254-938-2",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361d"
     ],
     "developmental_specific": true,
     "atp": "ATP18",
     "applies_from": "2023-11-23",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32022R0692",
     "index": "609-042-00-X"
    }
   ],
   "status": {
    "clp": "suspected"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Pendimethalin",
   "level": "suspected",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "pinoxaden (ISO); 8-(2,6-diethyl-4-methylphenyl)-7-oxo-1,2,4,5-tetrahydro-7H-pyrazolo[1,2-d][1,4,5]oxadiazepin-9-yl 2,2-dimethylpropanoate",
   "cas": "243973-20-8",
   "ec": "-",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361d"
     ],
     "developmental_specific": true,
     "atp": "ATP13",
     "applies_from": "2020-05-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32018R1480",
     "index": "607-726-00-2"
    }
   ],
   "status": {
    "clp": "suspected"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Pinoxaden",
   "level": "suspected",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "piperazine hydrochloride [1]",
   "cas": "",
   "ec": "228-042-7 [1]",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361fd"
     ],
     "developmental_specific": true,
     "atp": "ATP01",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32009R0790",
     "index": "612-241-00-4"
    }
   ],
   "status": {
    "clp": "suspected"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/piperazine_hydrochloride_[1]",
   "level": "suspected",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "piperazine; [solid]",
   "cas": "110-85-0",
   "ec": "203-808-3",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361fd"
     ],
     "developmental_specific": true,
     "atp": "ATP01",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32009R0790",
     "index": "612-057-00-4"
    },
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361fd"
     ],
     "developmental_specific": true,
     "atp": "ATP01",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32009R0790",
     "index": "612-057-01-1"
    }
   ],
   "status": {
    "clp": "suspected"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Piperazine",
   "level": "suspected",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "potassium permanganate",
   "cas": "7722-64-7",
   "ec": "231-760-3",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361d"
     ],
     "developmental_specific": true,
     "atp": "ATP13",
     "applies_from": "2020-05-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32018R1480",
     "index": "025-002-00-9"
    }
   ],
   "status": {
    "clp": "suspected"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Potassium_permanganate",
   "level": "suspected",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "profoxydim (ISO); 2-{](EZ)-1-[}(2RS)-2-(4-chlorophenoxy)propoxyimino{]butyl[}-3-hydroxy-5-(thian-3-yl)cyclohex-2-en-1-one",
   "cas": "139001-49-3",
   "ec": "-",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361d"
     ],
     "developmental_specific": true,
     "atp": "ATP01",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32009R0790",
     "index": "606-115-00-8"
    }
   ],
   "status": {
    "clp": "suspected"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    }
   },
   "wiki": null,
   "level": "suspected",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "propylenethiourea",
   "cas": "2122-19-2",
   "ec": "-",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361d"
     ],
     "developmental_specific": true,
     "atp": "CLP00",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "613-070-00-8"
    }
   ],
   "status": {
    "clp": "suspected"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    }
   },
   "wiki": null,
   "level": "suspected",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "pymetrozine (ISO); (E)-4,5-dihydro-6-methyl-4-(3-pyridylmethyleneamino)-1,2,4-triazin-3(2H)-one",
   "cas": "123312-89-0",
   "ec": "-",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361fd"
     ],
     "developmental_specific": true,
     "atp": "ATP15",
     "applies_from": "2022-03-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32020R1182",
     "index": "613-202-00-4"
    }
   ],
   "status": {
    "clp": "suspected"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Pymetrozine",
   "level": "suspected",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "pyraclostrobin (ISO); methyl N-(2-{[1-(4-chlorophenyl)-1H-pyrazol-3-yl]oxymethyl}phenyl) N-methoxy carbamate",
   "cas": "175013-18-0",
   "ec": "-",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361d"
     ],
     "developmental_specific": true,
     "atp": "ATP22",
     "applies_from": "2026-05-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32024R2564",
     "index": "613-272-00-6"
    }
   ],
   "status": {
    "clp": "suspected"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Pyraclostrobin",
   "level": "suspected",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "quinoclamine (ISO); 2-amino-3-chloro-1,4-naphthoquinone",
   "cas": "2797-51-5",
   "ec": "220-529-2",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361d"
     ],
     "developmental_specific": true,
     "atp": "ATP18",
     "applies_from": "2023-11-23",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32022R0692",
     "index": "606-154-00-0"
    }
   ],
   "status": {
    "clp": "suspected"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    }
   },
   "wiki": null,
   "level": "suspected",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "quizalofop-P-tefuryl (ISO); (+/–) tetrahydrofurfuryl (R)-2-[4-(6-chloroquinoxalin-2-yloxy)phenyloxy]propionate",
   "cas": "200509-41-7",
   "ec": "414-200-4",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361fd"
     ],
     "developmental_specific": true,
     "atp": "ATP13",
     "applies_from": "2020-05-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32018R1480",
     "index": "607-373-00-4"
    }
   ],
   "status": {
    "clp": "suspected"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    }
   },
   "wiki": null,
   "level": "suspected",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "salicylic acid",
   "cas": "69-72-7",
   "ec": "200-712-3",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361d"
     ],
     "developmental_specific": true,
     "atp": "ATP13",
     "applies_from": "2020-05-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32018R1480",
     "index": "607-732-00-5"
    }
   ],
   "status": {
    "clp": "suspected"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Salicylic_acid",
   "level": "suspected",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "salts of bromoxynil with the exception of those specified elsewhere in this Annex",
   "cas": "",
   "ec": "-",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361d"
     ],
     "developmental_specific": true,
     "atp": "CLP00",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "608-065-00-2"
    }
   ],
   "status": {
    "clp": "suspected"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    }
   },
   "wiki": null,
   "level": "suspected",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "salts of ioxynil with the exception of those specified elsewhere in this Annex",
   "cas": "",
   "ec": "-",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361d"
     ],
     "developmental_specific": true,
     "atp": "CLP00",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "608-066-00-8"
    }
   ],
   "status": {
    "clp": "suspected"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    }
   },
   "wiki": null,
   "level": "suspected",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "silver zinc zeolite (Zeolite, LTA framework type, surface-modified with silver and zinc ions); [This entry covers LTA (Linde Type A) framework type zeolite which has been surface-modified with both silver and zinc ions at contents Ag+ 0,5 %-6 %, Zn2 + 5 %-16 %, and potentially with phosphorus, NH4+, Mg2+ and/or Ca2+ each at level < 3 %]",
   "cas": "130328-20-0",
   "ec": "-",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361d"
     ],
     "developmental_specific": true,
     "atp": "ATP10",
     "applies_from": "2018-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32017R0776",
     "index": "047-003-00-3"
    }
   ],
   "status": {
    "clp": "suspected"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    }
   },
   "wiki": null,
   "level": "suspected",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "spirotetramat (ISO); (5s,8s)-3-(2,5-dimethylphenyl)-8-methoxy-2-oxo-1-azaspiro[4,5]dec-3-en-4-yl ethyl carbonate",
   "cas": "203313-25-1",
   "ec": "-",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361fd"
     ],
     "developmental_specific": true,
     "atp": "ATP07",
     "applies_from": "2017-01-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32015R1221",
     "index": "607-711-00-0"
    }
   ],
   "status": {
    "clp": "suspected"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Spirotetramat",
   "level": "suspected",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "spiroxamine (ISO); 8-tert-butyl-1,4-dioxaspiro[4.5]decan-2-ylmethyl(ethyl)(propyl)amine",
   "cas": "118134-30-8",
   "ec": "-",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361d"
     ],
     "developmental_specific": true,
     "atp": "ATP10",
     "applies_from": "2018-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32017R0776",
     "index": "612-150-00-X"
    }
   ],
   "status": {
    "clp": "suspected"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    }
   },
   "wiki": null,
   "level": "suspected",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "styrene",
   "cas": "100-42-5",
   "ec": "202-851-5",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361d"
     ],
     "developmental_specific": true,
     "atp": "ATP06",
     "applies_from": "2015-04-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32014R0605",
     "index": "601-026-00-0"
    }
   ],
   "status": {
    "clp": "suspected"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Styrene",
   "level": "suspected",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "sulcotrione (ISO); 2-[2-chloro-4-(methylsulfonyl)benzoyl]cyclohexane-1,3-dione",
   "cas": "99105-77-8",
   "ec": "-",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361d"
     ],
     "developmental_specific": true,
     "atp": "ATP05",
     "applies_from": "2015-01-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32013R0944",
     "index": "606-145-00-1"
    }
   ],
   "status": {
    "clp": "suspected"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    }
   },
   "wiki": null,
   "level": "suspected",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "tebuconazole (ISO); 1-(4-chlorophenyl)-4,4-dimethyl-3-(1,2,4-triazol-1-ylmethyl)pentan-3-ol",
   "cas": "107534-96-3",
   "ec": "403-640-2",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361d"
     ],
     "developmental_specific": true,
     "atp": "ATP07",
     "applies_from": "2017-01-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32015R1221",
     "index": "603-197-00-7"
    }
   ],
   "status": {
    "clp": "suspected"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Tebuconazole",
   "level": "suspected",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "tembotrione (ISO); 2-{2-chloro-4-(methylsulfonyl)-3-[(2,2,2-trifluoroethoxy)methyl]benzoyl}cyclohexane-1,3-dione",
   "cas": "335104-84-2",
   "ec": "-",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361d"
     ],
     "developmental_specific": true,
     "atp": "ATP07",
     "applies_from": "2017-01-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32015R1221",
     "index": "606-149-00-3"
    }
   ],
   "status": {
    "clp": "suspected"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    }
   },
   "wiki": null,
   "level": "suspected",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "tepraloxydim (ISO); (RS)-(EZ)-2-{]1-[}(2E)-3-chloroallyloxyimino{]propyl[}-3-hydroxy-5-perhydropyran-4-ylcyclohex-2-en-1-one",
   "cas": "149979-41-9",
   "ec": "-",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361fd"
     ],
     "developmental_specific": true,
     "atp": "ATP01",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32009R0790",
     "index": "606-116-00-3"
    }
   ],
   "status": {
    "clp": "suspected"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    }
   },
   "wiki": null,
   "level": "suspected",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "tetrasodium 3,3'-[[1,1'-biphenyl]-4,4'-diylbis(azo)]bis[5-amino-4-hydroxynaphthalene-2,7-disulphonate]; C.I. Direct Blue 6",
   "cas": "2602-46-2",
   "ec": "220-012-1",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361d"
     ],
     "developmental_specific": true,
     "atp": "CLP00",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "611-026-00-2"
    }
   ],
   "status": {
    "clp": "suspected"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/tetrasodium_3,3'-[[1,1'-biphenyl]-4,4'-diylbis(azo)]bis[5-amino-4-hydroxynaphthalene-2,7-disulphonate]",
   "level": "suspected",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "thiamethoxam (ISO); 3-(2-chloro-thiazol-5-ylmethyl)-5-methyl[1,3,5]oxadiazinan-4-ylidene-N-nitroamine",
   "cas": "153719-23-4",
   "ec": "428-650-4",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361fd"
     ],
     "developmental_specific": true,
     "atp": "ATP17",
     "applies_from": "2022-12-17",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32021R0849",
     "index": "613-267-00-9"
    }
   ],
   "status": {
    "clp": "suspected"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Thiamethoxam",
   "level": "suspected",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "thiourea; thiocarbamide",
   "cas": "62-56-6",
   "ec": "200-543-5",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361d"
     ],
     "developmental_specific": true,
     "atp": "CLP00",
     "applies_from": "2010-12-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32008R1272",
     "index": "612-082-00-0"
    }
   ],
   "status": {
    "clp": "suspected"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    }
   },
   "wiki": "https://en.wikipedia.org/wiki/Thiourea",
   "level": "suspected",
   "source_codes": [
    "clp"
   ]
  },
  {
   "name": "Tobacco smoking in pregnancy",
   "cas": "",
   "ec": "",
   "kind": "product",
   "sources": [
    {
     "label": "DysNet bibliography (peer-reviewed meta-analysis)",
     "code": "bib",
     "note": "Maternal smoking is associated with a higher risk of limb reduction defects in the pooled analysis of Hackshaw, Rodeck and Boniface (2011), among the references of the DysNet bibliography.",
     "url": "/knowledge/research-library/?q=smoking"
    }
   ],
   "status": {
    "bib": "suspected"
   },
   "jurisdictions": {
    "EU / EEA": "Legal; health warnings on packs are mandatory (Directive 2014/40/EU), including pregnancy-related warnings among the rotating texts."
   },
   "wiki": null,
   "level": "suspected",
   "source_codes": [
    "bib"
   ]
  },
  {
   "name": "trichloromethylstannane",
   "cas": "993-16-8",
   "ec": "213-608-8",
   "kind": "chemical",
   "sources": [
    {
     "label": "EU harmonised classification (CLP Annex VI)",
     "code": "clp",
     "category": "Repr. 2",
     "statements": [
      "H361d"
     ],
     "developmental_specific": true,
     "atp": "ATP05",
     "applies_from": "2015-01-01",
     "url": "https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32013R0944",
     "index": "050-025-00-6"
    }
   ],
   "status": {
    "clp": "suspected"
   },
   "jurisdictions": {
    "EU / EEA": {
     "labelling": "Mandatory hazard classification and labelling of the substance and of mixtures containing it (CLP Annex VI, harmonised).",
     "consumers": "Labelling required; no general ban on supply to the public for category 2.",
     "cosmetics": "Prohibited in cosmetics unless evaluated as safe by the SCCS (Regulation 1223/2009, Article 15(1))."
    }
   },
   "wiki": null,
   "level": "suspected",
   "source_codes": [
    "clp"
   ]
  }
 ]
}